C-C chemokine receptor 1 expression in human hematolymphoid neoplasia

Matthew W. Anderson, Shuchun Zhao, Weiyun Z. Ai, Robert Tibshirani, Ronald Levy, Izidore S. Lossos, Yasodha Natkunam

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Chemokine receptor 1 (CCR1) is a G protein-coupled receptor that binds to members of the C-C chemokine family. Recently, CCL3 (MIP-1α), a high-affinity CCR1 ligand, was identified as part of a model that independently predicts survival in patients with diffuse large B-cell lymphoma (DLBCL). However, the role of chemokine signaling in the pathogenesis of human lymphomas is unclear. In normal human hematopoietic tissues, we found CCR1 expression in intraepithelial B cells of human tonsil and granulocytic/monocytic cells in the bone marrow. Immunohistochemical analysis of 944 cases of hematolymphoid neoplasia identified CCR1 expression in a subset of B- and T-cell lymphomas, plasma cell myeloma, acute myeloid leukemia, and classical Hodgkin lymphoma. CCR1 expression correlated with the non-germinal center subtype of DLBCL but did not predict overall survival in follicular lymphoma. These data suggest that CCR1 may be useful for lymphoma classification and support a role for chemokine signaling in the pathogenesis of hematolymphoid neoplasia.

Original languageEnglish (US)
Pages (from-to)473-483
Number of pages11
JournalAmerican journal of clinical pathology
Volume133
Issue number3
DOIs
StatePublished - Mar 1 2010

Keywords

  • CCR1
  • Chemokine
  • Leukemia
  • Lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Anderson, M. W., Zhao, S., Ai, W. Z., Tibshirani, R., Levy, R., Lossos, I. S., & Natkunam, Y. (2010). C-C chemokine receptor 1 expression in human hematolymphoid neoplasia. American journal of clinical pathology, 133(3), 473-483. https://doi.org/10.1309/AJCP1TA3FLOQTMHF