Butyryl-cholinesterase is related to muscle mass and strength. A new biomarker to identify elderly subjects at risk of sarcopenia

Francesco Cacciatore, David Della Morte, Claudia Basile, Francesco Curcio, Ilaria Liguori, Mario Roselli, Gaetano Gargiulo, Gianluigi Galizia, Domenico Bonaduce, Pasquale Abete

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Aims: To determine the relationship between Butyryl-cholinesterase (α-glycoprotein synthesized in the liver, b-CHE) and muscle mass and strength. Methods: Muscle mass by bioimpedentiometer and muscle strength by grip strength were evaluated in 337 elderly subjects (mean age: 76.2 ± 6.7 years) admitted to comprehensive geriatric assessment. Results: b-CHE levels were lower in sarcopenic than in nonsarcopenic elderly subjects (p <0.01). Linear regression analysis demonstrated that b-CHE is linearly related with grip strength and muscular mass both in men and women (r = 0.45 and r = 0.33, p <0.01; r = 0.55 and r = 0.39, p <0.01; respectively). Multivariate analysis confirms this analysis. Conclusions: b-CHE is related to muscle mass and strength in elderly subjects. Thus, b-CHE may be considered to be a fair biomarker for identifying elderly subjects at risk of sarcopenia.

Original languageEnglish (US)
Pages (from-to)669-678
Number of pages10
JournalBiomarkers in Medicine
Volume9
Issue number7
DOIs
StatePublished - Jul 1 2015
Externally publishedYes

Keywords

  • biomarkers
  • inflammation
  • sarcopenia

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Drug Discovery

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