Butyryl-cholinesterase is related to muscle mass and strength. A new biomarker to identify elderly subjects at risk of sarcopenia

Francesco Cacciatore, David Della-Morte, Claudia Basile, Francesco Curcio, Ilaria Liguori, Mario Roselli, Gaetano Gargiulo, Gianluigi Galizia, Domenico Bonaduce, Pasquale Abete

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Aims: To determine the relationship between Butyryl-cholinesterase (α-glycoprotein synthesized in the liver, b-CHE) and muscle mass and strength. Methods: Muscle mass by bioimpedentiometer and muscle strength by grip strength were evaluated in 337 elderly subjects (mean age: 76.2 ± 6.7 years) admitted to comprehensive geriatric assessment. Results: b-CHE levels were lower in sarcopenic than in nonsarcopenic elderly subjects (p < 0.01). Linear regression analysis demonstrated that b-CHE is linearly related with grip strength and muscular mass both in men and women (r = 0.45 and r = 0.33, p < 0.01; r = 0.55 and r = 0.39, p < 0.01; respectively). Multivariate analysis confirms this analysis. Conclusions: b-CHE is related to muscle mass and strength in elderly subjects. Thus, b-CHE may be considered to be a fair biomarker for identifying elderly subjects at risk of sarcopenia.

Original languageEnglish (US)
Pages (from-to)669-678
Number of pages10
JournalBiomarkers in Medicine
Volume9
Issue number7
DOIs
StatePublished - Jul 2015
Externally publishedYes

Keywords

  • biomarkers
  • inflammation
  • sarcopenia

ASJC Scopus subject areas

  • Drug Discovery
  • Clinical Biochemistry
  • Biochemistry, medical

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