Burkitt's lymphoma variant of post-transplant lymphoproliferative disease (PTLD)

Melissa A. Pasquale, Debbie Weppler, Jon Smith, Michael Icardi, Alexandra Amador, Monica Gonzalez, Tomoaki Kato, Andreas Tzakis, Phillip Ruiz

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The occurrence of posttransplant lymphoproliferative disorder (PTLD) in solid organ allograft recipients can be quite varied in clinical presentation, histopathological characteristics and frequency. A variety of lymphomas can develop as a PTLD although some types appear infrequently and remain poorly understood in this clinical setting. In this report, we describe two cases of Burkitt's lymphoma presenting as a PTLD following liver transplantation. The recipients were 12 and 44 years of age and displayed gastrointestinal involvement by the tumors several years following transplant. The tumors displayed the typical histological features of Burkitt's lymphoma and were markedly positive for EBV. The tumors displayed similar immunophenotypic characteristics by flow cytometry and had rearrangements of the immunoglobulin J-H heavy chain. The tumors required aggressive chemotherapy and a cessation of immunosuppressive therapy. This report demonstrates that Burkitt's type lymphomas can develop in the posttransplant setting and that these tumors contain morphologic, cytofluorographic and molecular features identical to Burkitt's lymphomas that occur in non-transplant patients. Our experience is that these PTLD- Burkitt's lymphomas behave aggressively and require intensive chemotherapeutic intervention.

Original languageEnglish
Pages (from-to)105-108
Number of pages4
JournalPathology and Oncology Research
Volume8
Issue number2
StatePublished - Sep 18 2002

Fingerprint

Burkitt Lymphoma
Transplants
Neoplasms
Lymphoproliferative Disorders
Immunosuppressive Agents
Human Herpesvirus 4
Liver Transplantation
Allografts
Immunoglobulins
Lymphoma
Flow Cytometry
Drug Therapy

Keywords

  • Burkitt's lymphoma
  • PTLD

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

Cite this

Pasquale, M. A., Weppler, D., Smith, J., Icardi, M., Amador, A., Gonzalez, M., ... Ruiz, P. (2002). Burkitt's lymphoma variant of post-transplant lymphoproliferative disease (PTLD). Pathology and Oncology Research, 8(2), 105-108.

Burkitt's lymphoma variant of post-transplant lymphoproliferative disease (PTLD). / Pasquale, Melissa A.; Weppler, Debbie; Smith, Jon; Icardi, Michael; Amador, Alexandra; Gonzalez, Monica; Kato, Tomoaki; Tzakis, Andreas; Ruiz, Phillip.

In: Pathology and Oncology Research, Vol. 8, No. 2, 18.09.2002, p. 105-108.

Research output: Contribution to journalArticle

Pasquale, MA, Weppler, D, Smith, J, Icardi, M, Amador, A, Gonzalez, M, Kato, T, Tzakis, A & Ruiz, P 2002, 'Burkitt's lymphoma variant of post-transplant lymphoproliferative disease (PTLD)', Pathology and Oncology Research, vol. 8, no. 2, pp. 105-108.
Pasquale MA, Weppler D, Smith J, Icardi M, Amador A, Gonzalez M et al. Burkitt's lymphoma variant of post-transplant lymphoproliferative disease (PTLD). Pathology and Oncology Research. 2002 Sep 18;8(2):105-108.
Pasquale, Melissa A. ; Weppler, Debbie ; Smith, Jon ; Icardi, Michael ; Amador, Alexandra ; Gonzalez, Monica ; Kato, Tomoaki ; Tzakis, Andreas ; Ruiz, Phillip. / Burkitt's lymphoma variant of post-transplant lymphoproliferative disease (PTLD). In: Pathology and Oncology Research. 2002 ; Vol. 8, No. 2. pp. 105-108.
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