Burkitt's lymphoma variant of post-transplant lymphoproliferative disease (PTLD)

Melissa A. Pasquale, Debbie Weppler, Jon Smith, Michael Icardi, Alexandra Amador, Monica Gonzalez, Tomoaki Kato, Andreas Tzakis, Phillip Ruiz

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

The occurrence of posttransplant lymphoproliferative disorder (PTLD) in solid organ allograft recipients can be quite varied in clinical presentation, histopathological characteristics and frequency. A variety of lymphomas can develop as a PTLD although some types appear infrequently and remain poorly understood in this clinical setting. In this report, we describe two cases of Burkitt's lymphoma presenting as a PTLD following liver transplantation. The recipients were 12 and 44 years of age and displayed gastrointestinal involvement by the tumors several years following transplant. The tumors displayed the typical histological features of Burkitt's lymphoma and were markedly positive for EBV. The tumors displayed similar immunophenotypic characteristics by flow cytometry and had rearrangements of the immunoglobulin J-H heavy chain. The tumors required aggressive chemotherapy and a cessation of immunosuppressive therapy. This report demonstrates that Burkitt's type lymphomas can develop in the posttransplant setting and that these tumors contain morphologic, cytofluorographic and molecular features identical to Burkitt's lymphomas that occur in non-transplant patients. Our experience is that these PTLD- Burkitt's lymphomas behave aggressively and require intensive chemotherapeutic intervention.

Original languageEnglish (US)
Pages (from-to)105-108
Number of pages4
JournalPathology and Oncology Research
Volume8
Issue number2
DOIs
StatePublished - Jan 1 2002

Keywords

  • Burkitt's lymphoma
  • PTLD

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Burkitt's lymphoma variant of post-transplant lymphoproliferative disease (PTLD)'. Together they form a unique fingerprint.

  • Cite this

    Pasquale, M. A., Weppler, D., Smith, J., Icardi, M., Amador, A., Gonzalez, M., Kato, T., Tzakis, A., & Ruiz, P. (2002). Burkitt's lymphoma variant of post-transplant lymphoproliferative disease (PTLD). Pathology and Oncology Research, 8(2), 105-108. https://doi.org/10.1007/BF03033718