Brown fat expresses adiponectin in humans

Gianluca Iacobellis, Cira Di Gioia, Luigi Petramala, Caterina Chiappetta, Valentina Serra, Laura Zinnamosca, Cristiano Marinelli, Antonio Ciardi, Giorgio De Toma, Claudio Letizia

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20 Scopus citations

Abstract

The presence of brown adipose tissue (BAT) in humans is unclear. Pheochromocytomas (PHEO) are rare tumors of neuroectodermal origin which occur in 0.1-0.2% of patients with hypertension. We sought to evaluate the presence and activity of BAT surrounding adrenal PHEO in a well-studied sample of 11 patients who were diagnosed with PHEO and then underwent adrenalectomy. Areas of white fat (WAT) and BAT surrounding PHEO were obtained by Laser Capture Microdissection for analysis of uncoupling protein (UCP)-1 and adiponectin mRNA expression. Adiponectin and UCP-1 mRNA levels were significantly higher in BAT than in WAT (0.62 versus 0.15 and 362.4 versus 22.1, resp., P<0.01 for both). Adiponectin mRNA levels significantly correlated with urinary metanephrines (r=0.76, P<0.01), vanilly mandelic acid (VMA) (r=0.95, P<0.01), and serum adiponectin levels (r=0.95, P<0.01). Serum adiponectin levels significantly decreased (24.2±2 g/mL versus 18±11 g/mL, P<0.01) after adrenalectomy in PHEO subjects. This study provides the following findings: (1) BAT surrounding PHEO expresses adiponectin and UCP-1 mRNA, (2) expression of adiponectin mRNA is significantly higher in BAT than in WAT surrounding PHEO, and (3) catecholamines and serum adiponectin levels significantly correlate with BAT UCP-1 and adiponectin mRNA.

Original languageEnglish (US)
Article number126751
JournalInternational Journal of Endocrinology
Volume2013
DOIs
StatePublished - 2013

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems

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    Iacobellis, G., Di Gioia, C., Petramala, L., Chiappetta, C., Serra, V., Zinnamosca, L., Marinelli, C., Ciardi, A., De Toma, G., & Letizia, C. (2013). Brown fat expresses adiponectin in humans. International Journal of Endocrinology, 2013, [126751]. https://doi.org/10.1155/2013/126751