Bronchopulmonary dysplasia: NHLBI Workshop on the primary prevention of chronic lung diseases

Cindy T. McEvoy, Lucky Jain, Barbara Schmidt, Steven Abman, Eduardo Bancalari, Judy L. Aschner

Research output: Contribution to journalArticle

105 Scopus citations

Abstract

Bronchopulmonary dysplasia (BPD) is the most common complication of extreme preterm birth. Infants who develop BPD manifest aberrant or arrested pulmonary development and can experience lifelong alterations in cardiopulmonary function. Despite decades of promising research, primary prevention of BPD has proven elusive. This workshop report identifies current barriers to the conduct of primary prevention studies for BPD and causal pathways implicated in BPD pathogenesis. Throughout, we highlight promising areas for research to improve understanding of normal and aberrant lung development, distinguish BPD endotypes, and ascertain biomarkers for more targeted therapeutic approaches to prevention. We conclude with research recommendations and priorities to accelerate discovery and promote lung health in infants born preterm.

Original languageEnglish (US)
Pages (from-to)S146-S153
JournalAnnals of the American Thoracic Society
Volume11
Issue numberSUPPL. 3
DOIs
StatePublished - Apr 2014

Keywords

  • Lung injury
  • Lung repair
  • Mechanical ventilation
  • Normal preterm lung
  • Very preterm infants

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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