Bronchopulmonary dysplasia: Changes in pathogenesis, epidemiology and definition

Eduardo Bancalari, Nelson Claure, Ilene R.S. Sosenko

Research output: Contribution to journalReview articlepeer-review

301 Scopus citations


Bronchopulmonary dysplasia (BPD) continues to be one of the most common long-term complications associated with preterm birth. Its incidence is increasing as the survival of extreme premature infants improves, but its clinical presentation is milder than the original description of Northway and collaborators. In contrast to the classic BPD that was strongly related to mechanical injury and oxygen toxicity, current forms of the condition are more related to immaturity, perinatal infection and inflammation, persistent ductus arteriosus and disrupted alveolar and capillary development. Many different definitions of BPD have been proposed, most of which are based on the duration of supplemental oxygen requirement. The different definitions can produce strikingly different incidence figures, which may account for the wide variations in the condition reported in the literature. Some of the [imitations of the criteria most commonly used to diagnose BPD are discussed in this article.

Original languageEnglish (US)
Pages (from-to)63-71
Number of pages9
JournalSeminars in Neonatology
Issue number1
StatePublished - Feb 2003


  • BPD definition
  • BPD-epidemiology
  • BPD-pathogeneis
  • Bronchopulmonary
  • Dysplasia
  • Mechanical ventilation
  • Neonatal chronic lung disease
  • Oxygen therapy
  • Patent ductus arteriosus
  • Prematurity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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