Abstract
A double-blind crossover comparison was made of the effects of terbutaline, a new adrenergic drug with major action on beta 2 receptors, epinephrine, and saline, on pulmonary function in 16 patients with chronic bronchitis or emphysema and 9 patients with bronchial asthma. Serial determinations of lung volumes, dynamic mechanics of breathing, and distribution of ventilation were made after subcutaneous administration. Terbutaline, 0.5 mg, was a more effective bronchodilator and had a longer duration of action than epinephrine 0.25 mg, but was associated with a higher incidence of side effects. These were generally minor and transient and included tremor, nervousness, and palpitations. Terbutaline may be useful in the management of bronchospasm of asthma, chronic bronchitis, and emphysema.
| Original language | English |
|---|---|
| Pages (from-to) | 499-506 |
| Number of pages | 8 |
| Journal | Clinical Pharmacology and Therapeutics |
| Volume | 16 |
| Issue number | 3 PART 1 |
| State | Published - Sep 1 1974 |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Bronchodilator effects of terbutaline and epinephrine in obstructive lung disease. / Sackner, Marvin A.; Greeneltch, Ned; Silva, Grace; Wanner, Adam.
In: Clinical Pharmacology and Therapeutics, Vol. 16, No. 3 PART 1, 01.09.1974, p. 499-506.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bronchodilator effects of terbutaline and epinephrine in obstructive lung disease
AU - Sackner, Marvin A.
AU - Greeneltch, Ned
AU - Silva, Grace
AU - Wanner, Adam
PY - 1974/9/1
Y1 - 1974/9/1
N2 - A double-blind crossover comparison was made of the effects of terbutaline, a new adrenergic drug with major action on beta 2 receptors, epinephrine, and saline, on pulmonary function in 16 patients with chronic bronchitis or emphysema and 9 patients with bronchial asthma. Serial determinations of lung volumes, dynamic mechanics of breathing, and distribution of ventilation were made after subcutaneous administration. Terbutaline, 0.5 mg, was a more effective bronchodilator and had a longer duration of action than epinephrine 0.25 mg, but was associated with a higher incidence of side effects. These were generally minor and transient and included tremor, nervousness, and palpitations. Terbutaline may be useful in the management of bronchospasm of asthma, chronic bronchitis, and emphysema.
AB - A double-blind crossover comparison was made of the effects of terbutaline, a new adrenergic drug with major action on beta 2 receptors, epinephrine, and saline, on pulmonary function in 16 patients with chronic bronchitis or emphysema and 9 patients with bronchial asthma. Serial determinations of lung volumes, dynamic mechanics of breathing, and distribution of ventilation were made after subcutaneous administration. Terbutaline, 0.5 mg, was a more effective bronchodilator and had a longer duration of action than epinephrine 0.25 mg, but was associated with a higher incidence of side effects. These were generally minor and transient and included tremor, nervousness, and palpitations. Terbutaline may be useful in the management of bronchospasm of asthma, chronic bronchitis, and emphysema.
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UR - http://www.scopus.com/inward/citedby.url?scp=50849153377&partnerID=8YFLogxK
M3 - Article
C2 - 4606289
AN - SCOPUS:50849153377
VL - 16
SP - 499
EP - 506
JO - Clinical Pharmacology and Therapeutics
JF - Clinical Pharmacology and Therapeutics
SN - 0009-9236
IS - 3 PART 1
ER -