Bromodomain Protein BRD4 Is Essential for Hair Cell Function and Survival

Abhiraami Kannan-Sundhari, Clemer Abad, Marie E. Maloof, Nagi Ayad, Juan I. Young, Xue Zhong Liu, Katherina Walz

Research output: Contribution to journalArticle

Abstract

Hair cells (HCs) play crucial roles in perceiving sound, acceleration, and fluid motion. The tonotopic architecture of the sensory epithelium recognizes mechanical stimuli and convert them into electrical signals. The expression and regulation of the genes in the inner ear is very important to keep the sensory organ functional. Our study is the first to investigate the role of the epigenetic reader Brd4 in the mouse inner ear. We demonstrate that HC specific deletion of Brd4 in vivo in the mouse inner ear is sufficient to cause profound hearing loss (HL), degeneration of stereocilia, nerve fibers and HC loss postnatally in mouse; suggesting an important role in hearing function and maintenance.

Original languageEnglish (US)
Article number576654
JournalFrontiers in Cell and Developmental Biology
Volume8
DOIs
StatePublished - Sep 8 2020

Keywords

  • Brd4
  • function
  • hair cell loss
  • hair cells
  • hearing loss
  • survival

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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