Bromodomain Protein BRD4 Is Essential for Hair Cell Function and Survival

Abhiraami Kannan-Sundhari; Clemer Abad; Marie E. Maloof; Nagi G. Ayad; Juan I. Young; Xue Zhong Liu; Katherina Walz

doi:10.3389/fcell.2020.576654

Bromodomain Protein BRD4 Is Essential for Hair Cell Function and Survival

Abhiraami Kannan-Sundhari, Clemer Abad, Marie E. Maloof, Nagi G. Ayad, Juan I. Young, Xue Zhong Liu, Katherina Walz

Research output: Contribution to journal › Article › peer-review

Abstract

Hair cells (HCs) play crucial roles in perceiving sound, acceleration, and fluid motion. The tonotopic architecture of the sensory epithelium recognizes mechanical stimuli and convert them into electrical signals. The expression and regulation of the genes in the inner ear is very important to keep the sensory organ functional. Our study is the first to investigate the role of the epigenetic reader Brd4 in the mouse inner ear. We demonstrate that HC specific deletion of Brd4 in vivo in the mouse inner ear is sufficient to cause profound hearing loss (HL), degeneration of stereocilia, nerve fibers and HC loss postnatally in mouse; suggesting an important role in hearing function and maintenance.

Original language	English (US)
Article number	576654
Journal	Frontiers in Cell and Developmental Biology
Volume	8
DOIs	https://doi.org/10.3389/fcell.2020.576654
State	Published - Sep 8 2020

Keywords

Brd4
function
hair cell loss
hair cells
hearing loss
survival

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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10.3389/fcell.2020.576654

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title = "Bromodomain Protein BRD4 Is Essential for Hair Cell Function and Survival",

abstract = "Hair cells (HCs) play crucial roles in perceiving sound, acceleration, and fluid motion. The tonotopic architecture of the sensory epithelium recognizes mechanical stimuli and convert them into electrical signals. The expression and regulation of the genes in the inner ear is very important to keep the sensory organ functional. Our study is the first to investigate the role of the epigenetic reader Brd4 in the mouse inner ear. We demonstrate that HC specific deletion of Brd4 in vivo in the mouse inner ear is sufficient to cause profound hearing loss (HL), degeneration of stereocilia, nerve fibers and HC loss postnatally in mouse; suggesting an important role in hearing function and maintenance.",

keywords = "Brd4, function, hair cell loss, hair cells, hearing loss, survival",

author = "Abhiraami Kannan-Sundhari and Clemer Abad and Maloof, {Marie E.} and Ayad, {Nagi G.} and Young, {Juan I.} and Liu, {Xue Zhong} and Katherina Walz",

note = "Funding Information: Funding. This study was supported by NIH grants of R01DC005575 and R01DC012115 to XL. Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2020 Kannan-Sundhari, Abad, Maloof, Ayad, Young, Liu and Walz.",

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doi = "10.3389/fcell.2020.576654",

language = "English (US)",

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AU - Kannan-Sundhari, Abhiraami

AU - Abad, Clemer

AU - Maloof, Marie E.

AU - Ayad, Nagi G.

AU - Young, Juan I.

AU - Liu, Xue Zhong

AU - Walz, Katherina

N1 - Funding Information: Funding. This study was supported by NIH grants of R01DC005575 and R01DC012115 to XL. Publisher Copyright: © Copyright © 2020 Kannan-Sundhari, Abad, Maloof, Ayad, Young, Liu and Walz.

PY - 2020/9/8

Y1 - 2020/9/8

N2 - Hair cells (HCs) play crucial roles in perceiving sound, acceleration, and fluid motion. The tonotopic architecture of the sensory epithelium recognizes mechanical stimuli and convert them into electrical signals. The expression and regulation of the genes in the inner ear is very important to keep the sensory organ functional. Our study is the first to investigate the role of the epigenetic reader Brd4 in the mouse inner ear. We demonstrate that HC specific deletion of Brd4 in vivo in the mouse inner ear is sufficient to cause profound hearing loss (HL), degeneration of stereocilia, nerve fibers and HC loss postnatally in mouse; suggesting an important role in hearing function and maintenance.

AB - Hair cells (HCs) play crucial roles in perceiving sound, acceleration, and fluid motion. The tonotopic architecture of the sensory epithelium recognizes mechanical stimuli and convert them into electrical signals. The expression and regulation of the genes in the inner ear is very important to keep the sensory organ functional. Our study is the first to investigate the role of the epigenetic reader Brd4 in the mouse inner ear. We demonstrate that HC specific deletion of Brd4 in vivo in the mouse inner ear is sufficient to cause profound hearing loss (HL), degeneration of stereocilia, nerve fibers and HC loss postnatally in mouse; suggesting an important role in hearing function and maintenance.

KW - Brd4

KW - function

KW - hair cell loss

KW - hair cells

KW - hearing loss

KW - survival

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Bromodomain Protein BRD4 Is Essential for Hair Cell Function and Survival

Abstract

Keywords

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