Broadband superluminescent diode-based ultrahigh resolution optical coherence tomography for ophthalmic imaging

Dexi Zhu; Meixiao Shen; Hong Jiang; Ming Li; Michael R. Wang; Yuhong Wang; Lili Ge; Jia Qu; Jianhua Wang

doi:10.1117/1.3660314

Broadband superluminescent diode-based ultrahigh resolution optical coherence tomography for ophthalmic imaging

Dexi Zhu, Meixiao Shen, Hong Jiang, Ming Li, Michael R. Wang, Yuhong Wang, Lili Ge, Jia Qu, Jianhua Wang

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Spectral domain optical coherence tomography (SD-OCT) with ultrahigh resolution can be used to measure precise structures in the context of ophthalmic imaging. We designed an ultrahigh resolution SD-OCT system based on broadband superluminescent diode (SLD) as the light source. An axial resolution of 2.2 μm in tissue, a scan depth of 1.48 mm, and a high sensitivity of 93 dB were achieved by the spectrometer designed. The ultrahigh-resolution SD-OCT system was employed to image the human cornea and retina with a cross-section image of 2048 × 2048 pixels. Our research demonstrated that ultrahigh -resolution SD-OCT can be achieved using broadband SLD in a simple way.

Original language	English (US)
Article number	126006
Journal	Journal of Biomedical Optics
Volume	16
Issue number	12
DOIs	https://doi.org/10.1117/1.3660314
State	Published - Dec 2011

Keywords

Ophthalmic imaging
Optical coherence tomography

ASJC Scopus subject areas

Biomedical Engineering
Biomaterials
Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics

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title = "Broadband superluminescent diode-based ultrahigh resolution optical coherence tomography for ophthalmic imaging",

abstract = "Spectral domain optical coherence tomography (SD-OCT) with ultrahigh resolution can be used to measure precise structures in the context of ophthalmic imaging. We designed an ultrahigh resolution SD-OCT system based on broadband superluminescent diode (SLD) as the light source. An axial resolution of 2.2 μm in tissue, a scan depth of 1.48 mm, and a high sensitivity of 93 dB were achieved by the spectrometer designed. The ultrahigh-resolution SD-OCT system was employed to image the human cornea and retina with a cross-section image of 2048 × 2048 pixels. Our research demonstrated that ultrahigh -resolution SD-OCT can be achieved using broadband SLD in a simple way.",

keywords = "Ophthalmic imaging, Optical coherence tomography",

author = "Dexi Zhu and Meixiao Shen and Hong Jiang and Ming Li and Wang, {Michael R.} and Yuhong Wang and Lili Ge and Jia Qu and Jianhua Wang",

note = "Funding Information: This study has been supported by research grants, including NIH 1R21EY021012 (JW) UM SAC Award (JW), the NIH Center Grant P30 EY014801, and funding provided by Research to Prevent Blindness at the University of Miami. Visiting scholar activity was supported by research grants from the Zhejiang Science and Technology Program, Zhejiang, China (2010C03002) and the Affiliated Eye Hospital of Wenzhou Medical College (YNCX201005).",

year = "2011",

month = dec,

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journal = "Journal of Biomedical Optics",

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AU - Zhu, Dexi

AU - Shen, Meixiao

AU - Jiang, Hong

AU - Li, Ming

AU - Wang, Michael R.

AU - Wang, Yuhong

AU - Ge, Lili

AU - Qu, Jia

AU - Wang, Jianhua

N1 - Funding Information: This study has been supported by research grants, including NIH 1R21EY021012 (JW) UM SAC Award (JW), the NIH Center Grant P30 EY014801, and funding provided by Research to Prevent Blindness at the University of Miami. Visiting scholar activity was supported by research grants from the Zhejiang Science and Technology Program, Zhejiang, China (2010C03002) and the Affiliated Eye Hospital of Wenzhou Medical College (YNCX201005).

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N2 - Spectral domain optical coherence tomography (SD-OCT) with ultrahigh resolution can be used to measure precise structures in the context of ophthalmic imaging. We designed an ultrahigh resolution SD-OCT system based on broadband superluminescent diode (SLD) as the light source. An axial resolution of 2.2 μm in tissue, a scan depth of 1.48 mm, and a high sensitivity of 93 dB were achieved by the spectrometer designed. The ultrahigh-resolution SD-OCT system was employed to image the human cornea and retina with a cross-section image of 2048 × 2048 pixels. Our research demonstrated that ultrahigh -resolution SD-OCT can be achieved using broadband SLD in a simple way.

AB - Spectral domain optical coherence tomography (SD-OCT) with ultrahigh resolution can be used to measure precise structures in the context of ophthalmic imaging. We designed an ultrahigh resolution SD-OCT system based on broadband superluminescent diode (SLD) as the light source. An axial resolution of 2.2 μm in tissue, a scan depth of 1.48 mm, and a high sensitivity of 93 dB were achieved by the spectrometer designed. The ultrahigh-resolution SD-OCT system was employed to image the human cornea and retina with a cross-section image of 2048 × 2048 pixels. Our research demonstrated that ultrahigh -resolution SD-OCT can be achieved using broadband SLD in a simple way.

KW - Ophthalmic imaging

KW - Optical coherence tomography

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