Brigatinib for ALK-positive metastatic non-small-cell lung cancer: Design, development and place in therapy

Robert Ali; Junaid Arshad; Sofia Palacio; Raja Mudad

doi:10.2147/DDDT.S147499

Brigatinib for ALK-positive metastatic non-small-cell lung cancer: Design, development and place in therapy

Robert Ali, Junaid Arshad, Sofia Palacio, Raja Mudad

Medicine

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Despite the benefits of first and second generation anaplastic lymphoma kinase (ALK) inhibitors in the management of ALK-rearranged advanced non-small-cell lung cancer (NSCLC), the development of acquired resistance poses an ongoing dilemma. Brigatinib has demonstrated a wider spectrum of preclinical activity against crizotinib-resistant ALK mutant advanced NSCLC. The current review narrates a brief history of tyrosine kinases, the development and clinical background of brigatinib (including its pharmacology and molecular structure) and its use in ALK-positive NSCLC.

Original language	English (US)
Pages (from-to)	569-580
Number of pages	12
Journal	Drug design, development and therapy
Volume	13
DOIs	https://doi.org/10.2147/DDDT.S147499
State	Published - 2019

Keywords

ALK inhibitors
ALK positive
Brigatinib
Non-small cell lung cancer
TKI

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science
Drug Discovery

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title = "Brigatinib for ALK-positive metastatic non-small-cell lung cancer: Design, development and place in therapy",

abstract = "Despite the benefits of first and second generation anaplastic lymphoma kinase (ALK) inhibitors in the management of ALK-rearranged advanced non-small-cell lung cancer (NSCLC), the development of acquired resistance poses an ongoing dilemma. Brigatinib has demonstrated a wider spectrum of preclinical activity against crizotinib-resistant ALK mutant advanced NSCLC. The current review narrates a brief history of tyrosine kinases, the development and clinical background of brigatinib (including its pharmacology and molecular structure) and its use in ALK-positive NSCLC.",

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T1 - Brigatinib for ALK-positive metastatic non-small-cell lung cancer

T2 - Design, development and place in therapy

AU - Ali, Robert

AU - Arshad, Junaid

AU - Palacio, Sofia

AU - Mudad, Raja

PY - 2019

Y1 - 2019

N2 - Despite the benefits of first and second generation anaplastic lymphoma kinase (ALK) inhibitors in the management of ALK-rearranged advanced non-small-cell lung cancer (NSCLC), the development of acquired resistance poses an ongoing dilemma. Brigatinib has demonstrated a wider spectrum of preclinical activity against crizotinib-resistant ALK mutant advanced NSCLC. The current review narrates a brief history of tyrosine kinases, the development and clinical background of brigatinib (including its pharmacology and molecular structure) and its use in ALK-positive NSCLC.

AB - Despite the benefits of first and second generation anaplastic lymphoma kinase (ALK) inhibitors in the management of ALK-rearranged advanced non-small-cell lung cancer (NSCLC), the development of acquired resistance poses an ongoing dilemma. Brigatinib has demonstrated a wider spectrum of preclinical activity against crizotinib-resistant ALK mutant advanced NSCLC. The current review narrates a brief history of tyrosine kinases, the development and clinical background of brigatinib (including its pharmacology and molecular structure) and its use in ALK-positive NSCLC.

KW - ALK inhibitors

KW - ALK positive

KW - Brigatinib

KW - Non-small cell lung cancer

KW - TKI

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