Bridging the gaps between the histopathological and demographic risk factors of preterm birth in a Unique Miami inner-city population

Muthu Kumar Veerapen, Liset Pelaez, Jo Nell Efantis Potter, Lunthita Duthely, Rhea Birusingh, Evadnie Rampersaud, Olaf A. Bodamer, Maria Matilde Rodriguez

Research output: Contribution to journalArticlepeer-review

Abstract

We aim to identify the link between placental histological findings and obstetric reports to determine possible risk factors of spontaneous preterm birth (SPTB). We prospectively ascertained birth records and outcomes from all deliveries in our hospital in 1 year. Records were used to determine and stratify for either full-term or preterm spontaneous or indicated (I)" deliveries. We analyzed for risk factor association using χ2 tests and common odds ratio estimates (SPSS v21.0). Our cohort totaled 6088 deliveries: 236 IPTB, 43 SPTB, and 5809 term births. Largely Hispanic, we determined race, parity, prenatal care access, preeclampsia, gestational diabetes, and BMI to be highly associated with SPTB (p < 0.01). Histologically, placentas of women with SPTB were twice as likely to have chronic villitis. We found that chronic villitis is associated with SPTB. Results of this study can be used in increasing the understanding of SPTB.

Original languageEnglish (US)
Pages (from-to)226-233
Number of pages8
JournalFetal and Pediatric Pathology
Volume33
Issue number4
DOIs
StatePublished - Aug 2014

Keywords

  • Chronic villitis
  • Obstetrics
  • Placenta
  • Premature
  • Spontaneous preterm birth

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Pediatrics, Perinatology, and Child Health

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