Breast-conserving surgery vs. total mastectomy in patients with triple negative breast cancer in early stages: A propensity score analysis

Gabriel De-La-Cruz-Ku, Bryan Valcarcel, Zaida Morante, Mecker G. Möller, Sofia Lizandro, Lia P. Rebaza, Daniel Enriquez, Renato Luque, María G. Luján-Peche, Miguel E. Eyzaguirre-Sandoval, Antonella Saavedra, Cesar Razuri, Joseph A. Pinto, Hugo A. Fuentes, Silvia P. Neciosup, Henry L. Gomez

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Breast-conserving surgery (BCS) as an alternative to total mastectomy (TM) in patients with early-stage triple-negative breast cancer (TNBC) is not widely spread. OBJECTIVE: We aimed to compare the overall survival (OS) and disease-free survival (DFS) between both surgical approaches in early-stage TNBC patients at 10 years. METHODS: We conducted a retrospective cohort study in TNBC female patients with stage I-IIa, treated at a single-center during the period of 2000-2014. We estimated and compared the survival rates with the Kaplan Meier and Long-rank test. Propensity scores were calculated with the generalized boosted regression model and were used in the multivariate Cox regression analysis with the covariate adjustment method. RESULTS: We included 288 patients, 111 in the BCS vs. 177 in the TM group. The median follow-up was 102 months. Moreover, the patients in the BCS group had superior OS (85% vs. 81%, p = 0.56) and DFS (83% vs. 80%, p = 0.42) at 10 years. In the multivariate Cox analysis, BCS decreased the mortality risk (HR: 0.79, 95% CI: 0.37-1.67, p = 0.538), and the locoregional or distant recurrence risk (HR: 0.67, 95% CI: 0.32-1.41, p = 0.294), albeit with no statistical significance. CONCLUSION: BCS is a safe alternative to TM in Latin-American patients with early-stage TNBC.

Original languageEnglish (US)
Pages (from-to)29-35
Number of pages7
JournalBreast Disease
Volume39
Issue number1
DOIs
StatePublished - 2020

Keywords

  • adjuvant chemotherapy
  • breast-conserving surgery; overall survival
  • distant disease-free survival
  • Triple negative breast cancer neoplasm

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    De-La-Cruz-Ku, G., Valcarcel, B., Morante, Z., Möller, M. G., Lizandro, S., Rebaza, L. P., Enriquez, D., Luque, R., Luján-Peche, M. G., Eyzaguirre-Sandoval, M. E., Saavedra, A., Razuri, C., Pinto, J. A., Fuentes, H. A., Neciosup, S. P., & Gomez, H. L. (2020). Breast-conserving surgery vs. total mastectomy in patients with triple negative breast cancer in early stages: A propensity score analysis. Breast Disease, 39(1), 29-35. https://doi.org/10.3233/BD-190391