Abstract
Hand-held optical imaging devices are currently developed by several research groups as a noninvasive and non-ionizing method towards clinical imaging of breast cancer. The devices developed to date are typically utilized towards spectroscopic imaging via reflectance-based measurements. Additionally, a couple of devices have been used to perform 3D tomography with the addition of a second modality (e.g. ultrasound). A hand-held optical device that is unique in its ability to perform rapid 2D imaging and 3D tomography (without the use of a second modality) has been developed in our Optical Imaging laboratory. Herein, diffuse optical imaging studies are performed in breast cancer subjects. For these studies, the subject lay in a recliner chair and both breast tissues were imaged with the hand-held optical device which uses 785 nm laser source and an intensified CCD camera-based detector. Preliminary results demonstrate the ability to image invasive ductal carcinoma and lymphatic spread, as compared to the patient's medical records (e.g. xray, ultrasound, MRI). Multiple imaging studies with a subject undergoing chemotherapy demonstrated the potential to monitor response to treatment. Currently, studies are carried out to tomographically determine the 3D location of the tumor(s) in breast cancer subjects using the hand-held optical device.
| Original language | English |
|---|---|
| Title of host publication | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
| Volume | 8214 |
| DOIs | |
| State | Published - Jun 12 2012 |
| Event | Advanced Biomedical and Clinical Diagnostic Systems X - San Francisco, CA, United States Duration: Jan 22 2012 → Jan 24 2012 |
Other
| Other | Advanced Biomedical and Clinical Diagnostic Systems X |
|---|---|
| Country | United States |
| City | San Francisco, CA |
| Period | 1/22/12 → 1/24/12 |
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Keywords
- 3D tomography
- Breast cancer
- Clinical studies
- Coregistration
- Diffuse optical imaging
- Hand-held device
- Human subject
- Mammography
- Near-infrared
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Radiology Nuclear Medicine and imaging
Cite this
Breast cancer imaging and tomography using a hand-held optical imager. / Erickson, Sarah J.; Roman, Manuela; Gonzalez, Jean; Kiszonas, Richard; Lopez-Penalver, Cristina; Godavarty, Anuradha.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8214 2012. 82140Q.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Breast cancer imaging and tomography using a hand-held optical imager
AU - Erickson, Sarah J.
AU - Roman, Manuela
AU - Gonzalez, Jean
AU - Kiszonas, Richard
AU - Lopez-Penalver, Cristina
AU - Godavarty, Anuradha
PY - 2012/6/12
Y1 - 2012/6/12
N2 - Hand-held optical imaging devices are currently developed by several research groups as a noninvasive and non-ionizing method towards clinical imaging of breast cancer. The devices developed to date are typically utilized towards spectroscopic imaging via reflectance-based measurements. Additionally, a couple of devices have been used to perform 3D tomography with the addition of a second modality (e.g. ultrasound). A hand-held optical device that is unique in its ability to perform rapid 2D imaging and 3D tomography (without the use of a second modality) has been developed in our Optical Imaging laboratory. Herein, diffuse optical imaging studies are performed in breast cancer subjects. For these studies, the subject lay in a recliner chair and both breast tissues were imaged with the hand-held optical device which uses 785 nm laser source and an intensified CCD camera-based detector. Preliminary results demonstrate the ability to image invasive ductal carcinoma and lymphatic spread, as compared to the patient's medical records (e.g. xray, ultrasound, MRI). Multiple imaging studies with a subject undergoing chemotherapy demonstrated the potential to monitor response to treatment. Currently, studies are carried out to tomographically determine the 3D location of the tumor(s) in breast cancer subjects using the hand-held optical device.
AB - Hand-held optical imaging devices are currently developed by several research groups as a noninvasive and non-ionizing method towards clinical imaging of breast cancer. The devices developed to date are typically utilized towards spectroscopic imaging via reflectance-based measurements. Additionally, a couple of devices have been used to perform 3D tomography with the addition of a second modality (e.g. ultrasound). A hand-held optical device that is unique in its ability to perform rapid 2D imaging and 3D tomography (without the use of a second modality) has been developed in our Optical Imaging laboratory. Herein, diffuse optical imaging studies are performed in breast cancer subjects. For these studies, the subject lay in a recliner chair and both breast tissues were imaged with the hand-held optical device which uses 785 nm laser source and an intensified CCD camera-based detector. Preliminary results demonstrate the ability to image invasive ductal carcinoma and lymphatic spread, as compared to the patient's medical records (e.g. xray, ultrasound, MRI). Multiple imaging studies with a subject undergoing chemotherapy demonstrated the potential to monitor response to treatment. Currently, studies are carried out to tomographically determine the 3D location of the tumor(s) in breast cancer subjects using the hand-held optical device.
KW - 3D tomography
KW - Breast cancer
KW - Clinical studies
KW - Coregistration
KW - Diffuse optical imaging
KW - Hand-held device
KW - Human subject
KW - Mammography
KW - Near-infrared
UR - http://www.scopus.com/inward/record.url?scp=84861922536&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84861922536&partnerID=8YFLogxK
U2 - 10.1117/12.908528
DO - 10.1117/12.908528
M3 - Conference contribution
AN - SCOPUS:84861922536
SN - 9780819488572
VL - 8214
BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
ER -