Breast Biopsy for Calcifications in Nonpalpable Breast Lesions: A Prospective Study

Dido Franceschi, Joseph Crowe, Robert Zollinger, Renate Duchesneau, Robert Shenk, Gladys Stefanek, Jerry M. Shuck

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


We prospectively studied 239 consecutive patients who underwent breast biopsy for 277 nonpalpable lesions characterized by mammographic microcalcifications. Clinical and mammographic characteristics were correlated with histologic findings in an attempt to identify patients more likely to have early breast cancer. The distribution of clinical risk factors was equal between patients with benign or malignant outcomes. The predominant Wolfe pattern on mammography was P2 (38%); however, no relationship was observed between the Wolfe pattern and malignancy. A marked correlation was observed between malignancy and small lesions, more than 15 calcifications, and calcifications in a linear or branching pattern. Twenty-four percent (n=67) of the biopsy specimens contained either ductal or lobular breast cancer. This study highlights the necessity of an aggressive approach toward suspicious calcifications found by mammography.

Original languageEnglish (US)
Pages (from-to)170-173
Number of pages4
JournalArchives of Surgery
Issue number2
StatePublished - Feb 1990
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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