Breakdown of the normal optic nerve head blood-brain barrier following acute elevation of intraocular pressure in experimental animals

R. L. Radius, Douglas Anderson

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Five hours of elevated intraocular pressure produced evidence of an altered blood-brain barrier at the optic nerve head in 27 of 29 monkey eyes. The change in vascular permeability was documented by fluorescein angiography (18 of 21 eyes), by Evans blue fluorescence microscopy (21 of 23 eyes), or by both methods. Leakage occurred from major blood vessels as well as from microvasculature of the nerve head. In 22 eyes, rapid axonal transport was studied after intravitreal injection of tritiated leucine. In 18 of these 22 eyes, autoradiography demonstrated a local interruption of axonal transport. In 15 eyes examined by all three methods, leakage from microvasculature (as opposed to leakage from the major vessels) was loosely associated with severe and widespread blockade of axonal transport at the lamina cribrosa. Although cause-and-effect relationships are not proved, ischemia may be responsible both for the focal endothelial damage with breakdown of the normal blood-brain barrier and for the local abnormalities of axonal transport.

Original languageEnglish
Pages (from-to)244-255
Number of pages12
JournalInvestigative Ophthalmology and Visual Science
Volume19
Issue number3
StatePublished - Dec 1 1980

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Optic Disk
Blood-Brain Barrier
Intraocular Pressure
Axonal Transport
Microvessels
Evans Blue
Intravitreal Injections
Fluorescein Angiography
Capillary Permeability
Autoradiography
Fluorescence Microscopy
Leucine
Haplorhini
Blood Vessels
Ischemia

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Breakdown of the normal optic nerve head blood-brain barrier following acute elevation of intraocular pressure in experimental animals. / Radius, R. L.; Anderson, Douglas.

In: Investigative Ophthalmology and Visual Science, Vol. 19, No. 3, 01.12.1980, p. 244-255.

Research output: Contribution to journalArticle

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