Brainstem glioma

Clinical manifestations of meningeal gliomatosis

R. J. Packer, J. Allen, S. Nielsen, Carol Petito, M. Deck, B. Jereb

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Brainstem gliomas of children are variably malignant tumors that rarely have been reported to produce subarachnoid dissemination. Nevertheless, during a two-year period, 5 of 15 such patients treated by us developed symptoms of leptomeningeal metastases. The diagnosis of an anaplastic astrocytoma with meningeal gliomatosis was confirmed postmortem in all 5. In 3 children, meningeal symptoms preceded other signs of posterior fossa recurrence. Symptoms of meningeal gliomatosis included local or radiating back pain (5 patients), segmental weakness (3), paresthesia (2), and incontinence (2). Myelography, performed in 4 patients, was the most useful diagnostic technique, disclosing multiple intradural filling defects or a high degree of block in 3 patients. Although the cerebrospinal fluid was abnormal in all 4 examined patients in only 1 were malignant cells detected. Prolonged survival, which appears to predispose to dissemination of adult malignant gliomas, was not an apparent factor in our patients.

Original languageEnglish
Pages (from-to)177-182
Number of pages6
JournalAnnals of Neurology
Volume14
Issue number2
StatePublished - Sep 23 1983
Externally publishedYes

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Glioma
Brain Stem
Myelography
Paresthesia
Astrocytoma
Cerebrospinal Fluid
Neoplasm Metastasis
Recurrence
Survival
Neoplasms

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Packer, R. J., Allen, J., Nielsen, S., Petito, C., Deck, M., & Jereb, B. (1983). Brainstem glioma: Clinical manifestations of meningeal gliomatosis. Annals of Neurology, 14(2), 177-182.

Brainstem glioma : Clinical manifestations of meningeal gliomatosis. / Packer, R. J.; Allen, J.; Nielsen, S.; Petito, Carol; Deck, M.; Jereb, B.

In: Annals of Neurology, Vol. 14, No. 2, 23.09.1983, p. 177-182.

Research output: Contribution to journalArticle

Packer, RJ, Allen, J, Nielsen, S, Petito, C, Deck, M & Jereb, B 1983, 'Brainstem glioma: Clinical manifestations of meningeal gliomatosis', Annals of Neurology, vol. 14, no. 2, pp. 177-182.
Packer RJ, Allen J, Nielsen S, Petito C, Deck M, Jereb B. Brainstem glioma: Clinical manifestations of meningeal gliomatosis. Annals of Neurology. 1983 Sep 23;14(2):177-182.
Packer, R. J. ; Allen, J. ; Nielsen, S. ; Petito, Carol ; Deck, M. ; Jereb, B. / Brainstem glioma : Clinical manifestations of meningeal gliomatosis. In: Annals of Neurology. 1983 ; Vol. 14, No. 2. pp. 177-182.
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