Tuberculoma cerebral en placa. Presentación atípica de tuberculosis en el sistema nervioso central

Eduardo Bessolo; Sebastián Villate; José Alfredo Arroyo; Graciela Rango; Gustavo Andrés Ortiz

doi:10.1016/j.neuarg.2016.08.003

Tuberculoma cerebral en placa. Presentación atípica de tuberculosis en el sistema nervioso central

Translated title of the contribution: Brain tuberculoma brain en plaque. Atypical presentation of tuberculosis in the central nervous system

Eduardo Bessolo, Sebastián Villate, José Alfredo Arroyo, Graciela Rango, Gustavo Andrés Ortiz

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: Tuberculous plaque is an uncommon and atypical presentation of CNS tuberculosis. Specific diagnosis can be difficult and this condition may not be included in the differential of intracranial lesions. Clinical case: A 64-year-old male patient with history of myelodyslastic syndrome, remote tuberculosis and dermal mycosis, who developed first-time seizure with complete symptomatic resolution. The brain MRI showed a cortico-subcortical right frontal lesion, with involvement of the dura, which enhanced with contrast agent. Biochemical and serological studies were unrevealing, but a skin biopsy showed granulomatous reaction. Antitubercu-losis treatment with four drugs was started, with clinical and radiological improvement. Conclusion: CNS tuberculosis is rare, but may occur in apparently immunocompetent patients. Tuberculous plaque should be considered in the differential diagnosis for intracranial tumors.

Translated title of the contribution	Brain tuberculoma brain en plaque. Atypical presentation of tuberculosis in the central nervous system
Original language	Spanish
Pages (from-to)	195-198
Number of pages	4
Journal	Neurologica Argentina
Volume	9
Issue number	3
DOIs	https://doi.org/10.1016/j.neuarg.2016.08.003
State	Published - Jul 1 2017
Externally published	Yes

Keywords

Myelodysplastic syndrome
Pachymeningitis
Tuberculoma en plaque

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "Tuberculoma cerebral en placa. Presentaci{\'o}n at{\'i}pica de tuberculosis en el sistema nervioso central",

abstract = "Introduction: Tuberculous plaque is an uncommon and atypical presentation of CNS tuberculosis. Specific diagnosis can be difficult and this condition may not be included in the differential of intracranial lesions. Clinical case: A 64-year-old male patient with history of myelodyslastic syndrome, remote tuberculosis and dermal mycosis, who developed first-time seizure with complete symptomatic resolution. The brain MRI showed a cortico-subcortical right frontal lesion, with involvement of the dura, which enhanced with contrast agent. Biochemical and serological studies were unrevealing, but a skin biopsy showed granulomatous reaction. Antitubercu-losis treatment with four drugs was started, with clinical and radiological improvement. Conclusion: CNS tuberculosis is rare, but may occur in apparently immunocompetent patients. Tuberculous plaque should be considered in the differential diagnosis for intracranial tumors.",

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AU - Bessolo, Eduardo

AU - Villate, Sebastián

AU - Arroyo, José Alfredo

AU - Rango, Graciela

AU - Ortiz, Gustavo Andrés

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Introduction: Tuberculous plaque is an uncommon and atypical presentation of CNS tuberculosis. Specific diagnosis can be difficult and this condition may not be included in the differential of intracranial lesions. Clinical case: A 64-year-old male patient with history of myelodyslastic syndrome, remote tuberculosis and dermal mycosis, who developed first-time seizure with complete symptomatic resolution. The brain MRI showed a cortico-subcortical right frontal lesion, with involvement of the dura, which enhanced with contrast agent. Biochemical and serological studies were unrevealing, but a skin biopsy showed granulomatous reaction. Antitubercu-losis treatment with four drugs was started, with clinical and radiological improvement. Conclusion: CNS tuberculosis is rare, but may occur in apparently immunocompetent patients. Tuberculous plaque should be considered in the differential diagnosis for intracranial tumors.

AB - Introduction: Tuberculous plaque is an uncommon and atypical presentation of CNS tuberculosis. Specific diagnosis can be difficult and this condition may not be included in the differential of intracranial lesions. Clinical case: A 64-year-old male patient with history of myelodyslastic syndrome, remote tuberculosis and dermal mycosis, who developed first-time seizure with complete symptomatic resolution. The brain MRI showed a cortico-subcortical right frontal lesion, with involvement of the dura, which enhanced with contrast agent. Biochemical and serological studies were unrevealing, but a skin biopsy showed granulomatous reaction. Antitubercu-losis treatment with four drugs was started, with clinical and radiological improvement. Conclusion: CNS tuberculosis is rare, but may occur in apparently immunocompetent patients. Tuberculous plaque should be considered in the differential diagnosis for intracranial tumors.

KW - Myelodysplastic syndrome

KW - Pachymeningitis

KW - Tuberculoma en plaque

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