Brain-targeted delivery of peptides

Nicholas Bodor, Peter Buchwald

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

A major impediment in the development of peptide-based therapeutics is our inability to successfully deliver and maintain them at their intended site of action. The present review will focus on a novel, unique, chemicalenzymatic approach designated as molecular packaging that represents an extension of the redox chemical delivery system (CDS) approach and can provide brain- and retina- targeted delivery of peptides through rational drug design. This has made possible the non-invasive brain delivery of neuropeptides such as Leuenkephalin-, TRH-, and kyotorphin-analogs in pharmacologically significant and therapeutically effective amounts.

Original languageEnglish (US)
Pages (from-to)100-104
Number of pages5
JournalAmerican Pharmaceutical Review
Volume9
Issue number1
StatePublished - Jan 1 2006

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ASJC Scopus subject areas

  • Pharmaceutical Science

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