Brain studies of mouse models for neurogenetic disorders using in vivo magnetic resonance imaging (MRI)

R. Frank Kooy; Marleen Verhoye; Vance Lemmon; Annemie Van Der Linden

doi:10.1038/sj.ejhg.5200606

Brain studies of mouse models for neurogenetic disorders using in vivo magnetic resonance imaging (MRI)

R. Frank Kooy, Marleen Verhoye, Vance Lemmon, Annemie Van Der Linden

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

Magnetic resonance imaging (MRI) is a technique commonly used to detect neural abnormalities in routine clinical practice. It is perhaps less well known that the technique can be adapted to measure various anatomical and physiological features of small laboratory rodents. This review focuses on the potential of the MRI technique to image the brain of (transgenic) mouse models for neurological diseases, and aims to introduce these exciting new technological developments to the non-specialist reader.

Original language	English (US)
Pages (from-to)	153-159
Number of pages	7
Journal	European Journal of Human Genetics
Volume	9
Issue number	3
DOIs	https://doi.org/10.1038/sj.ejhg.5200606
State	Published - 2001
Externally published	Yes

Keywords

Brain structure
Fragile X syndrome
Knockout mouse
Magnetic resonance imaging
Mental retardation
X-linked hydrocephalus

ASJC Scopus subject areas

Genetics(clinical)

Access to Document

10.1038/sj.ejhg.5200606

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title = "Brain studies of mouse models for neurogenetic disorders using in vivo magnetic resonance imaging (MRI)",

abstract = "Magnetic resonance imaging (MRI) is a technique commonly used to detect neural abnormalities in routine clinical practice. It is perhaps less well known that the technique can be adapted to measure various anatomical and physiological features of small laboratory rodents. This review focuses on the potential of the MRI technique to image the brain of (transgenic) mouse models for neurological diseases, and aims to introduce these exciting new technological developments to the non-specialist reader.",

keywords = "Brain structure, Fragile X syndrome, Knockout mouse, Magnetic resonance imaging, Mental retardation, X-linked hydrocephalus",

author = "Kooy, {R. Frank} and Marleen Verhoye and Vance Lemmon and {Van Der Linden}, Annemie",

note = "Funding Information: Financial support for the research performed in Antwerp was obtained through grants from the University of Antwerp, the Belgian National Fund for Scientific Research - Flanders (FWO), the Fragile X research foundation (FRAXA) and from the EC. Research in Vance Lemmon's laboratory is supported by the NEI and NINDS.",

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AU - Kooy, R. Frank

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AU - Lemmon, Vance

AU - Van Der Linden, Annemie

N1 - Funding Information: Financial support for the research performed in Antwerp was obtained through grants from the University of Antwerp, the Belgian National Fund for Scientific Research - Flanders (FWO), the Fragile X research foundation (FRAXA) and from the EC. Research in Vance Lemmon's laboratory is supported by the NEI and NINDS.

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KW - Mental retardation

KW - X-linked hydrocephalus

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