Brain Structural and Amyloid Correlates of Recovery From Semantic Interference in Cognitively Normal Individuals With or Without Family History of Late-Onset Alzheimer's Disease

Carolina Abulafia, David Loewenstein, Rosie Curiel Cid, Bárbara Duarte-Abritta, Stella M. Sánchez, Daniel E. Vigo, Mariana N. Castro, Lucas J. Drucaroff, Silvia Vázquez, Gustavo Sevlever, Charles Nemeroff, Salvador M. Guinjoan, Mirta F. Villarreal

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Failure to recover from proactive semantic interference (frPSI) has been shown to be more sensitive than traditional cognitive measures in different populations with preclinical Alzheimer's disease. The authors sought to characterize the structural and amyloid in vivo correlates of frPSI in cognitively normal offspring of patients with late-onset Alzheimer's disease (O-LOAD), compared with individuals without a family history of neurodegenerative disorders (CS). The authors evaluated the LASSI-L, a test tapping frPSI and other types of semantic interference and delayed recall on the RAVLT, along with 3-T MRI volumetry and positron emission tomography Pittsburgh compound B, in 27 O-LOAD and 18 CS with equivalent age, sex, years of education, ethnicity, premorbid intelligence, and mood symptoms. Recovery from proactive semantic interference (frPSI) and RAVLT delayed recall were lower in O-LOAD cases. Structural correlates of both cognitive dimensions were different in CS and O-LOAD, involving brain regions concerned with autonomic, motor, and motivational control in the former, and regions traditionally implicated in Alzheimer's disease in the latter. Better recovery from retroactive semantic interference was associated with less amyloid load in the left temporal lobe in O-LOAD but not CS. In middle-aged cognitively normal individuals with one parent affected with LOAD, frPSI was impaired compared with persons without a family history of LOAD. The neuroimaging correlates of such cognitive measure in those with one parent with LOAD involve Alzheimer's-relevant brain regions even at a relatively young age.

Original languageEnglish (US)
Pages (from-to)25-36
Number of pages12
JournalThe Journal of neuropsychiatry and clinical neurosciences
Volume31
Issue number1
DOIs
StatePublished - Dec 1 2019

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Semantics
Amyloid
Alzheimer Disease
Brain
Sex Education
Temporal Lobe
Intelligence
Neuroimaging
Neurodegenerative Diseases
Positron-Emission Tomography
Population

Keywords

  • Alzheimer’s Disease
  • Cognitive Disorders
  • Imaging Techniques

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Brain Structural and Amyloid Correlates of Recovery From Semantic Interference in Cognitively Normal Individuals With or Without Family History of Late-Onset Alzheimer's Disease. / Abulafia, Carolina; Loewenstein, David; Curiel Cid, Rosie; Duarte-Abritta, Bárbara; Sánchez, Stella M.; Vigo, Daniel E.; Castro, Mariana N.; Drucaroff, Lucas J.; Vázquez, Silvia; Sevlever, Gustavo; Nemeroff, Charles; Guinjoan, Salvador M.; Villarreal, Mirta F.

In: The Journal of neuropsychiatry and clinical neurosciences, Vol. 31, No. 1, 01.12.2019, p. 25-36.

Research output: Contribution to journalArticle

Abulafia, Carolina ; Loewenstein, David ; Curiel Cid, Rosie ; Duarte-Abritta, Bárbara ; Sánchez, Stella M. ; Vigo, Daniel E. ; Castro, Mariana N. ; Drucaroff, Lucas J. ; Vázquez, Silvia ; Sevlever, Gustavo ; Nemeroff, Charles ; Guinjoan, Salvador M. ; Villarreal, Mirta F. / Brain Structural and Amyloid Correlates of Recovery From Semantic Interference in Cognitively Normal Individuals With or Without Family History of Late-Onset Alzheimer's Disease. In: The Journal of neuropsychiatry and clinical neurosciences. 2019 ; Vol. 31, No. 1. pp. 25-36.
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AU - Vigo, Daniel E.

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