Brain SIRT1 mediates metabolic homeostasis and neuroprotection

Jing Xu, Charlie W. Jackson, Nathalie Khoury, Iris Escobar, Miguel A. Perez-Pinzon

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

Sirtuins are evolutionarily conserved proteins that use nicotinamide adenine dinucleotide (NAD+) as a co-substrate in their enzymatic reactions. There are seven proteins (SIRT1-7) in the human sirtuin family, among which SIRT1 is themost conserved and characterized. SIRT1 in the brain, in particular, within the hypothalamus, plays crucial roles in regulating systemic energy homeostasis and circadian rhythm. Apart from this, SIRT1 has also been found to mediate beneficial effects in neurological diseases. In this review, we will first summarize how SIRT1 in the brain relates to obesity, type 2 diabetes, and circadian synchronization, and then we discuss the neuroprotective roles of brain SIRT1 in the context of cerebral ischemia and neurodegenerative disorders.

Original languageEnglish (US)
Article number702
JournalFrontiers in Endocrinology
Volume9
DOIs
StatePublished - 2018

Keywords

  • Alzheimer’s disease
  • Cerebral ischemia
  • Circadian rhythms
  • Obesity
  • Parkinson’s disease
  • Sirt1
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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