Brain SIRT1 mediates metabolic homeostasis and neuroprotection

Jing Xu; Charlie W. Jackson; Nathalie Khoury; Iris Escobar; Miguel A. Perez-Pinzon

doi:10.3389/fendo.2018.00702

Brain SIRT1 mediates metabolic homeostasis and neuroprotection

Jing Xu, Charlie W. Jackson, Nathalie Khoury, Iris Escobar, Miguel A. Perez-Pinzon

Neurology

Research output: Contribution to journal › Review article › peer-review

52 Scopus citations

Abstract

Sirtuins are evolutionarily conserved proteins that use nicotinamide adenine dinucleotide (NAD⁺) as a co-substrate in their enzymatic reactions. There are seven proteins (SIRT1-7) in the human sirtuin family, among which SIRT1 is themost conserved and characterized. SIRT1 in the brain, in particular, within the hypothalamus, plays crucial roles in regulating systemic energy homeostasis and circadian rhythm. Apart from this, SIRT1 has also been found to mediate beneficial effects in neurological diseases. In this review, we will first summarize how SIRT1 in the brain relates to obesity, type 2 diabetes, and circadian synchronization, and then we discuss the neuroprotective roles of brain SIRT1 in the context of cerebral ischemia and neurodegenerative disorders.

Original language	English (US)
Article number	702
Journal	Frontiers in Endocrinology
Volume	9
DOIs	https://doi.org/10.3389/fendo.2018.00702
State	Published - 2018

Keywords

Alzheimer’s disease
Cerebral ischemia
Circadian rhythms
Obesity
Parkinson’s disease
Sirt1
Type 2 diabetes mellitus

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism

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10.3389/fendo.2018.00702

Cite this

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title = "Brain SIRT1 mediates metabolic homeostasis and neuroprotection",

abstract = "Sirtuins are evolutionarily conserved proteins that use nicotinamide adenine dinucleotide (NAD+) as a co-substrate in their enzymatic reactions. There are seven proteins (SIRT1-7) in the human sirtuin family, among which SIRT1 is themost conserved and characterized. SIRT1 in the brain, in particular, within the hypothalamus, plays crucial roles in regulating systemic energy homeostasis and circadian rhythm. Apart from this, SIRT1 has also been found to mediate beneficial effects in neurological diseases. In this review, we will first summarize how SIRT1 in the brain relates to obesity, type 2 diabetes, and circadian synchronization, and then we discuss the neuroprotective roles of brain SIRT1 in the context of cerebral ischemia and neurodegenerative disorders.",

keywords = "Alzheimer{\textquoteright}s disease, Cerebral ischemia, Circadian rhythms, Obesity, Parkinson{\textquoteright}s disease, Sirt1, Type 2 diabetes mellitus",

author = "Jing Xu and Jackson, {Charlie W.} and Nathalie Khoury and Iris Escobar and Perez-Pinzon, {Miguel A.}",

note = "Funding Information: This work was financially supported by the NIH/NINDS grants NS45676, NS097658, and NS34773. Publisher Copyright: {\textcopyright} 2018 Xu, Jackson, Khoury, Escobar and Perez-Pinzon.",

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doi = "10.3389/fendo.2018.00702",

language = "English (US)",

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AU - Jackson, Charlie W.

AU - Khoury, Nathalie

AU - Escobar, Iris

AU - Perez-Pinzon, Miguel A.

PY - 2018

Y1 - 2018

N2 - Sirtuins are evolutionarily conserved proteins that use nicotinamide adenine dinucleotide (NAD+) as a co-substrate in their enzymatic reactions. There are seven proteins (SIRT1-7) in the human sirtuin family, among which SIRT1 is themost conserved and characterized. SIRT1 in the brain, in particular, within the hypothalamus, plays crucial roles in regulating systemic energy homeostasis and circadian rhythm. Apart from this, SIRT1 has also been found to mediate beneficial effects in neurological diseases. In this review, we will first summarize how SIRT1 in the brain relates to obesity, type 2 diabetes, and circadian synchronization, and then we discuss the neuroprotective roles of brain SIRT1 in the context of cerebral ischemia and neurodegenerative disorders.

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KW - Alzheimer’s disease

KW - Cerebral ischemia

KW - Circadian rhythms

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KW - Parkinson’s disease

KW - Sirt1

KW - Type 2 diabetes mellitus

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Brain SIRT1 mediates metabolic homeostasis and neuroprotection

Abstract

Keywords

ASJC Scopus subject areas

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