Brain sensitivity to anoxia in fish as reflected by changes in extracellular K+ activity

G. E. Nilsson, M. Perez-Pinzon, K. Dimberg, S. Winberg

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Most vertebrates have a very limited tolerance to anoxia. The only exceptions to this rule are found among ectothermic species, notably crucian carp (Carassius carassius) and freshwater turtles. It has been assumed that the brains of these species are less sensitive to anoxia than ectothermic brains in general. However, it has not been possible to exclude that anoxia- intolerant species like rainbow trout (Oncorhynchus mykiss) die from heart failure rather than brain failure during anoxia, and that the average ectothermic brain is actually rather insensitive to anoxia. By simultaneously measuring the effect of anoxia on brain extracellular K+ activity ([K+](o)), blood pressure, and heart rate in rainbow trout, we show that the rainbow trout brain rapidly loses ion homeostasis during anoxia, despite an initial increase in blood pressure. The rainbow trout brain showed a sudden transient increase in [K+](o) (suggesting a rapid depolarization) after ~30 min of anoxia at 10°C. At the same time the blood pressure was still close to the normoxic value. In a comparative experiment, crucian carp was found to maintain a low brain [K+](o) for at least 6 h of anoxia. Thus the results suggest that the rainbow trout brain is anoxia-intolerant in itself, and that its ability to maintain ion gradients during anoxia is very much lower than that of crucian carp. If temperature differences are taken into account, the anoxia sensitivity of the rainbow trout brain is comparable to that of mammals.

Original languageEnglish (US)
Pages (from-to)R250-R253
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume264
Issue number2 33-2
DOIs
StatePublished - 1993

Keywords

  • blood pressure
  • Carassius carassius
  • crucian carp
  • heart failure
  • hypoxia
  • ion homeostasis
  • Oncorhynchus mykiss
  • rainbow trout

ASJC Scopus subject areas

  • Physiology

Fingerprint Dive into the research topics of 'Brain sensitivity to anoxia in fish as reflected by changes in extracellular K<sup>+</sup> activity'. Together they form a unique fingerprint.

  • Cite this