Brain-reactive antibodies and the aids dementia complex

Mahendra Kumar, Lionel Resnick, David A. Loewenstein, Joseph Berger, Carl Eisdorfer

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Abstract

To determine the role of autoantibodies in the development of the AIDS dementia complex, brain-reactive antibodies (BRAs) were assayed in 30 sera samples obtained from AIDS patients. Eighteen samples were obtained from AIDS patients with neuropsychological complications, and 12 samples were obtained from patients without any neuropsychological involvement. BRAs were analyzed using strips of nitrocellulose electroblots as a source of antigen, and were prepared from a sample of normal human parahippocampal tissue subjected to SDS-PAGE. Fourteen of 18 patients with neuropsychological complications and 4 of 12 patients without such complications were positive for BRAs to protein with M(r) of 45,000-50,000.

Original languageEnglish (US)
Pages (from-to)469-471
Number of pages3
JournalJournal of Acquired Immune Deficiency Syndromes
Volume2
Issue number5
StatePublished - Oct 1989

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Keywords

  • AIDS dementia complex
  • Brain-reactive antibodies

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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