Brain-reactive antibodies and the AIDS dementia complex

Mahendra Kumar, L. Resnick, David Loewenstein, J. Berger, C. Eisdorfer

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

To determine the role of autoantibodies in the development of the AIDS dementia complex, brain-reactive antibodies (BRAs) were assayed in 30 sera samples obtained from AIDS patients. Eighteen samples were obtained from AIDS patients with neuropsychological complications, and 12 samples were obtained from patients without any neuropsychological involvement. BRAs were analyzed using strips of nitrocellulose electroblots as a source of antigen, and were prepared from a sample of normal human parahippocampal tissue subjected to SDS-PAGE. Fourteen of 18 patients with neuropsychological complications and 4 of 12 patients without such complications were positive for BRAs to protein with M(r) of 45,000-50,000.

Original languageEnglish
Pages (from-to)469-471
Number of pages3
JournalJournal of Acquired Immune Deficiency Syndromes
Volume2
Issue number5
StatePublished - Jan 1 1989

Fingerprint

AIDS Dementia Complex
Antibodies
Brain
Acquired Immunodeficiency Syndrome
Collodion
Autoantibodies
Polyacrylamide Gel Electrophoresis
Antigens
Serum
Proteins

ASJC Scopus subject areas

  • Virology
  • Immunology and Allergy

Cite this

Brain-reactive antibodies and the AIDS dementia complex. / Kumar, Mahendra; Resnick, L.; Loewenstein, David; Berger, J.; Eisdorfer, C.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 2, No. 5, 01.01.1989, p. 469-471.

Research output: Contribution to journalArticle

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