Brain processing of contagious itch in patients with atopic dermatitis

Christina Schut, Hideki Mochizuki, Shoshana K. Grossman, Andrew C. Lin, Christopher J. Conklin, Feroze B. Mohamed, Uwe Gieler, Joerg Kupfer, Gil Yosipovitch

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Several studies show that itch and scratching cannot only be induced by pruritogens like histamine or cowhage, but also by the presentation of certain (audio-) visual stimuli like pictures on crawling insects or videos showing other people scratching. This phenomenon is coined "Contagious itch" (CI). Due to the fact that CI is more profound in patients with the chronic itchy skin disease atopic dermatitis (AD), we believe that it is highly relevant to study brain processing of CI in this group. Knowledge on brain areas involved in CI in AD-patients can provide us with useful hints regarding non-invasive treatments that AD-patients could profit from when they are confronted with itch-inducing situations in daily life. Therefore, this study investigated the brain processing of CI in AD-patients. 11 AD-patients underwent fMRI scans during the presentation of an itch inducing experimental video (EV) and a non-itch inducing control video (CV). Perfusion based brain activity was measured using arterial spin labeling functional MRI. As expected, the EV compared to the CV led to an increase in itch and scratching (p < 0.05). CI led to a significant increase in brain activity in the supplementary motor area, left ventral striatum and right orbitofrontal cortex (threshold: p < 0.001; cluster size k > 50). Moreover, itch induced by watching the EV was by trend correlated with activity in memory-related regions including the temporal cortex and the (pre-) cuneus as well as the posterior operculum, a brain region involved in itch processing (threshold: p < 0.005; cluster size k > 50). These findings suggest that the fronto-striatal circuit, which is associated with the desire to scratch, might be a target region for non-invasive treatments in AD patients.

Original languageEnglish (US)
Article number1267
JournalFrontiers in Physiology
Volume8
Issue numberJUL
DOIs
StatePublished - Jul 25 2017

Fingerprint

Atopic Dermatitis
Brain
Magnetic Resonance Imaging
Corpus Striatum
Occipital Lobe
Temporal Lobe
Skin Diseases
Histamine
Insects
Perfusion
Therapeutics

Keywords

  • Atopic dermatitis
  • Contagious itch
  • Functional MRI
  • Orbitofrontal cortex
  • Striatum
  • Supplementary motor area

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Brain processing of contagious itch in patients with atopic dermatitis. / Schut, Christina; Mochizuki, Hideki; Grossman, Shoshana K.; Lin, Andrew C.; Conklin, Christopher J.; Mohamed, Feroze B.; Gieler, Uwe; Kupfer, Joerg; Yosipovitch, Gil.

In: Frontiers in Physiology, Vol. 8, No. JUL, 1267, 25.07.2017.

Research output: Contribution to journalArticle

Schut, C, Mochizuki, H, Grossman, SK, Lin, AC, Conklin, CJ, Mohamed, FB, Gieler, U, Kupfer, J & Yosipovitch, G 2017, 'Brain processing of contagious itch in patients with atopic dermatitis', Frontiers in Physiology, vol. 8, no. JUL, 1267. https://doi.org/10.3389/fpsyg.2017.01267
Schut, Christina ; Mochizuki, Hideki ; Grossman, Shoshana K. ; Lin, Andrew C. ; Conklin, Christopher J. ; Mohamed, Feroze B. ; Gieler, Uwe ; Kupfer, Joerg ; Yosipovitch, Gil. / Brain processing of contagious itch in patients with atopic dermatitis. In: Frontiers in Physiology. 2017 ; Vol. 8, No. JUL.
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