Abstract
CONTINUOUS OXYGEN DELIVERY and CO2 clearance are paramount in the maintenance of normal brain function and tissue integrity. Under normal conditions, aerobic metabolism is the major source of energy in the brain, but this system may be compromised by the interruption of substrate delivery and disturbances in cerebral metabolism. These disruptions are major factors contributing to ischemic and hypoxic brain damage resulting from traumatic brain injury, stroke, and subarachnoid hemorrhage. There is evidence that mitochondrial function also is reduced after injury. Furthermore, early impairment of cerebral blood flow in patients with severe injury correlates with poor tissue oxygenation and may be an important parameter in secondary damage. Recent advances in brain tissue monitoring in the intensive care unit and operating room have made it possible to continuously measure tissue oxygen tension and temperature, as well as certain aspects of brain metabolism and neurochemistry. Therefore, it is important to understand the physiological process and the pathophysiology produced by these events. This is Part I of a two-part review that analyzes the physiology of cerebral oxygenation and metabolism as well as some of the pathological mechanisms involved in ischemic and traumatic brain injuries. Brain tissue monitoring techniques will be examined in the second article of this two-part series. To understand cerebral oxygenation, it is important to understand cerebral blood flow, energy production, ischemia, acidosis, generation of reactive oxygen species, and mitochondrial failure. These issues provide the basis of knowledge regarding brain bioenergetics and are important topics to understand when developing new approaches to patient care.
| Original language | English |
|---|---|
| Pages (from-to) | 289-302 |
| Number of pages | 14 |
| Journal | Neurosurgery |
| Volume | 51 |
| Issue number | 2 |
| DOIs | |
| State | Published - Aug 1 2002 |
| Externally published | Yes |
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Keywords
- Cerebral blood flow regulation
- Cerebral oxygenation
- Energy production
- Mitochondria function
ASJC Scopus subject areas
- Clinical Neurology
- Surgery
Cite this
Brain oxygenation and energy metabolism : Part I - Biological function and pathophysiology. / Zauner, Alois; Daugherty, Wilson P.; Bullock, Ross; Warner, David S.; Selman, Warren R.; Dempsey, Robert J.
In: Neurosurgery, Vol. 51, No. 2, 01.08.2002, p. 289-302.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Brain oxygenation and energy metabolism
T2 - Part I - Biological function and pathophysiology
AU - Zauner, Alois
AU - Daugherty, Wilson P.
AU - Bullock, Ross
AU - Warner, David S.
AU - Selman, Warren R.
AU - Dempsey, Robert J.
PY - 2002/8/1
Y1 - 2002/8/1
N2 - CONTINUOUS OXYGEN DELIVERY and CO2 clearance are paramount in the maintenance of normal brain function and tissue integrity. Under normal conditions, aerobic metabolism is the major source of energy in the brain, but this system may be compromised by the interruption of substrate delivery and disturbances in cerebral metabolism. These disruptions are major factors contributing to ischemic and hypoxic brain damage resulting from traumatic brain injury, stroke, and subarachnoid hemorrhage. There is evidence that mitochondrial function also is reduced after injury. Furthermore, early impairment of cerebral blood flow in patients with severe injury correlates with poor tissue oxygenation and may be an important parameter in secondary damage. Recent advances in brain tissue monitoring in the intensive care unit and operating room have made it possible to continuously measure tissue oxygen tension and temperature, as well as certain aspects of brain metabolism and neurochemistry. Therefore, it is important to understand the physiological process and the pathophysiology produced by these events. This is Part I of a two-part review that analyzes the physiology of cerebral oxygenation and metabolism as well as some of the pathological mechanisms involved in ischemic and traumatic brain injuries. Brain tissue monitoring techniques will be examined in the second article of this two-part series. To understand cerebral oxygenation, it is important to understand cerebral blood flow, energy production, ischemia, acidosis, generation of reactive oxygen species, and mitochondrial failure. These issues provide the basis of knowledge regarding brain bioenergetics and are important topics to understand when developing new approaches to patient care.
AB - CONTINUOUS OXYGEN DELIVERY and CO2 clearance are paramount in the maintenance of normal brain function and tissue integrity. Under normal conditions, aerobic metabolism is the major source of energy in the brain, but this system may be compromised by the interruption of substrate delivery and disturbances in cerebral metabolism. These disruptions are major factors contributing to ischemic and hypoxic brain damage resulting from traumatic brain injury, stroke, and subarachnoid hemorrhage. There is evidence that mitochondrial function also is reduced after injury. Furthermore, early impairment of cerebral blood flow in patients with severe injury correlates with poor tissue oxygenation and may be an important parameter in secondary damage. Recent advances in brain tissue monitoring in the intensive care unit and operating room have made it possible to continuously measure tissue oxygen tension and temperature, as well as certain aspects of brain metabolism and neurochemistry. Therefore, it is important to understand the physiological process and the pathophysiology produced by these events. This is Part I of a two-part review that analyzes the physiology of cerebral oxygenation and metabolism as well as some of the pathological mechanisms involved in ischemic and traumatic brain injuries. Brain tissue monitoring techniques will be examined in the second article of this two-part series. To understand cerebral oxygenation, it is important to understand cerebral blood flow, energy production, ischemia, acidosis, generation of reactive oxygen species, and mitochondrial failure. These issues provide the basis of knowledge regarding brain bioenergetics and are important topics to understand when developing new approaches to patient care.
KW - Cerebral blood flow regulation
KW - Cerebral oxygenation
KW - Energy production
KW - Mitochondria function
UR - http://www.scopus.com/inward/record.url?scp=0036705670&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036705670&partnerID=8YFLogxK
U2 - 10.1097/00006123-200208000-00003
DO - 10.1097/00006123-200208000-00003
M3 - Article
C2 - 12182767
AN - SCOPUS:0036705670
VL - 51
SP - 289
EP - 302
JO - Neurosurgery
JF - Neurosurgery
SN - 0148-396X
IS - 2
ER -