Brain metastases in malignant pleural mesothelioma. Case report and review of the literature.

K. S. Sridhar, A. M. Hussein, P. Ganjei, Richard J Thurer, N. Raskin, E. J. Beattie

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Recent advances in pleural malignant mesothelioma include the sequential use of palliative surgery, perioperative radiation therapy, and systemic chemotherapy. Radical treatments may not only palliate but also improve survival in some patients. The latter may be associated with the appearance of metastases in unusual sites including the central nervous system. In malignant mesothelioma, brain metastases were previously reported in 19 patients at autopsy and in only 1 patient antemortem. We detail the clinical presentation in the second patient with pleural malignant mesothelioma thus far reported to develop brain metastases. The difficulties in diagnosis, the role of immunoperoxidase stains in malignant mesothelioma, excellent tolerance of different modalities of treatment, and a review of the literature of brain metastases in mesothelioma are discussed. Based on our report, the possibility of brain metastases should be investigated by careful clinical examination prior to a radical treatment in patients with progressive refractory mesothelioma.

Original languageEnglish
Pages (from-to)222-228
Number of pages7
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume12
Issue number3
StatePublished - Jun 1 1989

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Neoplasm Metastasis
Brain
Mesothelioma
Palliative Care
Autopsy
Coloring Agents
Radiotherapy
Therapeutics
Central Nervous System
Malignant Mesothelioma
Drug Therapy
Survival

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Sridhar, K. S., Hussein, A. M., Ganjei, P., Thurer, R. J., Raskin, N., & Beattie, E. J. (1989). Brain metastases in malignant pleural mesothelioma. Case report and review of the literature. American Journal of Clinical Oncology: Cancer Clinical Trials, 12(3), 222-228.

Brain metastases in malignant pleural mesothelioma. Case report and review of the literature. / Sridhar, K. S.; Hussein, A. M.; Ganjei, P.; Thurer, Richard J; Raskin, N.; Beattie, E. J.

In: American Journal of Clinical Oncology: Cancer Clinical Trials, Vol. 12, No. 3, 01.06.1989, p. 222-228.

Research output: Contribution to journalArticle

Sridhar, KS, Hussein, AM, Ganjei, P, Thurer, RJ, Raskin, N & Beattie, EJ 1989, 'Brain metastases in malignant pleural mesothelioma. Case report and review of the literature.', American Journal of Clinical Oncology: Cancer Clinical Trials, vol. 12, no. 3, pp. 222-228.
Sridhar, K. S. ; Hussein, A. M. ; Ganjei, P. ; Thurer, Richard J ; Raskin, N. ; Beattie, E. J. / Brain metastases in malignant pleural mesothelioma. Case report and review of the literature. In: American Journal of Clinical Oncology: Cancer Clinical Trials. 1989 ; Vol. 12, No. 3. pp. 222-228.
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