Brain Metabolism in Autism: Resting Cerebral Glucose Utilization Rates as Measured With Positron Emission Tomography

Judith M. Rumsey, Ranjan Duara, Cheryl Grady, Judith L. Rapoport, Richard A. Margolin, Stanley I. Rapoport, Neal R. Cutler

Research output: Contribution to journalArticle

142 Scopus citations

Abstract

The cerebral metabolic rate for glucose was studied in ten men (x̄ age = 26 years) with well-documented histories of infantile autism and in 15 age-matched normal male controls using positron emission tomography and (F-18) 2-fluoro-2-deoxy-D-glucose. Positron emission tomography was completed during rest, with reduced visual and auditory stimulation. While the autistic groups as a whole showed significantly elevated glucose utilization in widespread regions of the brain, there was considerable overlap between the two groups. No brain region showed a reduced metabolic rate in the autistic group. Significantly more autistic, as compared with control, subjects showed extreme relative metabolic rates (ratios of regional metabolic rates to whole brain rates and asymmetries) in one or more brain regions.

Original languageEnglish (US)
Pages (from-to)448-455
Number of pages8
JournalArchives of General Psychiatry
Volume42
Issue number5
DOIs
StatePublished - May 1985

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Brain Metabolism in Autism: Resting Cerebral Glucose Utilization Rates as Measured With Positron Emission Tomography'. Together they form a unique fingerprint.

  • Cite this

    Rumsey, J. M., Duara, R., Grady, C., Rapoport, J. L., Margolin, R. A., Rapoport, S. I., & Cutler, N. R. (1985). Brain Metabolism in Autism: Resting Cerebral Glucose Utilization Rates as Measured With Positron Emission Tomography. Archives of General Psychiatry, 42(5), 448-455. https://doi.org/10.1001/archpsyc.1985.01790280026003