Brain lipid peroxidation induced by postischemic reoxygenation in vitro: Effect of vitamin E

S. Yoshida, R. Busto, M. Santiso, M. D. Ginsberg

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

The aerobic incubation of brain after a period of ischemia induced lipid peroxidation. The effect was greatest in vitamin E-deficient rats, intermediate in vitamin E-normal rats, and least in animals supplemented with vitamin E. In contrast, nitrogen incubation following ischemia produced a small effect only in the vitamin E-deficient animals. It appears that reoxygenation is required for lipid peroxides to accumulate in the brain. However, a trace of oxygen remaining during extreme ischemic hypoxia may be sufficient to cause slow propagation of free radical reactions when the vitamin E level is low.

Original languageEnglish (US)
Pages (from-to)466-469
Number of pages4
JournalJournal of Cerebral Blood Flow and Metabolism
Volume4
Issue number3
DOIs
StatePublished - 1984

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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