Brain lipid peroxidation induced by postischemic reoxygenation in vitro: Effect of vitamin E

S. Yoshida; R. Busto; M. Santiso; M. D. Ginsberg

doi:10.1038/jcbfm.1984.66

Brain lipid peroxidation induced by postischemic reoxygenation in vitro: Effect of vitamin E

S. Yoshida, R. Busto, M. Santiso, M. D. Ginsberg

Neurology

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

The aerobic incubation of brain after a period of ischemia induced lipid peroxidation. The effect was greatest in vitamin E-deficient rats, intermediate in vitamin E-normal rats, and least in animals supplemented with vitamin E. In contrast, nitrogen incubation following ischemia produced a small effect only in the vitamin E-deficient animals. It appears that reoxygenation is required for lipid peroxides to accumulate in the brain. However, a trace of oxygen remaining during extreme ischemic hypoxia may be sufficient to cause slow propagation of free radical reactions when the vitamin E level is low.

Original language	English (US)
Pages (from-to)	466-469
Number of pages	4
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	4
Issue number	3
DOIs	https://doi.org/10.1038/jcbfm.1984.66
State	Published - 1984

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cardiology and Cardiovascular Medicine

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abstract = "The aerobic incubation of brain after a period of ischemia induced lipid peroxidation. The effect was greatest in vitamin E-deficient rats, intermediate in vitamin E-normal rats, and least in animals supplemented with vitamin E. In contrast, nitrogen incubation following ischemia produced a small effect only in the vitamin E-deficient animals. It appears that reoxygenation is required for lipid peroxides to accumulate in the brain. However, a trace of oxygen remaining during extreme ischemic hypoxia may be sufficient to cause slow propagation of free radical reactions when the vitamin E level is low.",

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AU - Ginsberg, M. D.

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