Abstract
The aerobic incubation of brain after a period of ischemia induced lipid peroxidation. The effect was greatest in vitamin E-deficient rats, intermediate in vitamin E-normal rats, and least in animals supplemented with vitamin E. In contrast, nitrogen incubation following ischemia produced a small effect only in the vitamin E-deficient animals. It appears that reoxygenation is required for lipid peroxides to accumulate in the brain. However, a trace of oxygen remaining during extreme ischemic hypoxia may be sufficient to cause slow propagation of free radical reactions when the vitamin E level is low.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 466-469 |
| Number of pages | 4 |
| Journal | Journal of Cerebral Blood Flow and Metabolism |
| Volume | 4 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1984 |
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
- Cardiology and Cardiovascular Medicine