Brain imaging: Aging and dementia

N. R. Cutler, R. Duara, H. Creasey

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The brain imaging techniques of positron emission tomography using [18F]-fluoro-2-deoxy-D-glucose, and computed tomography, together with neuropsychological tests, were used to examine overall brain function and anatomy in three study populations: healthy men at different ages, patients with presumptive Alzheimer's disease, and adults with Down's syndrome. Brain glucose use did not differ with age, whereas an age-related decrement in gray matter volume was found on computed tomographic assessment in healthy subjects. Memory deficits were found to precede significant reductions in brain glucose utilization in mild to moderate Alzheimer's dementia. Furthermore, differences between language and visuoconstructive impairments in patients with mild to moderate Alzheimer's disease were related to hemispheric asymmetry of brain metabolism. Brain glucose utilization was found to be significantly elevated in young adults with Down's syndrome, compared with controls. The importance of establishing strict criteria for selecting control subjects and patients is explained in relation to the findings.

Original languageEnglish
Pages (from-to)355-369
Number of pages15
JournalAnnals of Internal Medicine
Volume101
Issue number3
StatePublished - Jan 1 1984
Externally publishedYes

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Neuroimaging
Dementia
Brain
Alzheimer Disease
Down Syndrome
Glucose
Neuropsychological Tests
Memory Disorders
Deoxyglucose
Positron-Emission Tomography
Young Adult
Anatomy
Healthy Volunteers
Language
Tomography
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cutler, N. R., Duara, R., & Creasey, H. (1984). Brain imaging: Aging and dementia. Annals of Internal Medicine, 101(3), 355-369.

Brain imaging : Aging and dementia. / Cutler, N. R.; Duara, R.; Creasey, H.

In: Annals of Internal Medicine, Vol. 101, No. 3, 01.01.1984, p. 355-369.

Research output: Contribution to journalArticle

Cutler, NR, Duara, R & Creasey, H 1984, 'Brain imaging: Aging and dementia', Annals of Internal Medicine, vol. 101, no. 3, pp. 355-369.
Cutler NR, Duara R, Creasey H. Brain imaging: Aging and dementia. Annals of Internal Medicine. 1984 Jan 1;101(3):355-369.
Cutler, N. R. ; Duara, R. ; Creasey, H. / Brain imaging : Aging and dementia. In: Annals of Internal Medicine. 1984 ; Vol. 101, No. 3. pp. 355-369.
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