TY - JOUR
T1 - Brain functional connectivity in individuals with callosotomy and agenesis of the corpus callosum
T2 - A systematic review
AU - Mancuso, Lorenzo
AU - Uddin, Lucina Q.
AU - Nani, Andrea
AU - Costa, Tommaso
AU - Cauda, Franco
N1 - Funding Information:
This study was supported by the Fondazione Carlo Molo, Turin, Italy to FC and R01MH107549 from the National Institute of Mental Health to LQU .
PY - 2019/10
Y1 - 2019/10
N2 - In the absence of the corpus callosum due to either surgical transection or congenital agenesis, the interhemispheric exchange of information is disrupted, as emphasized by several clinical studies. In such cases, a reduction of interhemispheric functional connectivity, that is, an increased independence of the functional signals of the two disconnected hemispheres, is expected to occur. A growing literature has investigated this hypothesis, and a number of studies were able to confirm it. However, this increased independence is not always observed, especially in congenital agenesis, in which the functional signals of the two hemispheres are often found to be characterized by synchronization or correlation. The extent of these counterintuitive findings and possible explanations are discussed. Overall, these findings highlight both methodological and theoretical considerations that emphasize the importance of subcortical structures, the preservation of which may underlie alternative pathways of functional connectivity and interhemispheric communication.
AB - In the absence of the corpus callosum due to either surgical transection or congenital agenesis, the interhemispheric exchange of information is disrupted, as emphasized by several clinical studies. In such cases, a reduction of interhemispheric functional connectivity, that is, an increased independence of the functional signals of the two disconnected hemispheres, is expected to occur. A growing literature has investigated this hypothesis, and a number of studies were able to confirm it. However, this increased independence is not always observed, especially in congenital agenesis, in which the functional signals of the two hemispheres are often found to be characterized by synchronization or correlation. The extent of these counterintuitive findings and possible explanations are discussed. Overall, these findings highlight both methodological and theoretical considerations that emphasize the importance of subcortical structures, the preservation of which may underlie alternative pathways of functional connectivity and interhemispheric communication.
KW - Anterior commissure
KW - Commissures
KW - Corpus callosum agenesis
KW - Functional connectivity
KW - Homotopic connectivity
KW - Interhemispheric connectivity
KW - Split-brain
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U2 - 10.1016/j.neubiorev.2019.07.004
DO - 10.1016/j.neubiorev.2019.07.004
M3 - Review article
C2 - 31412269
AN - SCOPUS:85071520313
VL - 105
SP - 231
EP - 248
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
SN - 0149-7634
ER -