Brain energy metabolism and mitochondrial dysfunction in acute and chronic hepatic encephalopathy

Kakulavarapu V. Rama Rao, Michael D. Norenberg

Research output: Contribution to journalReview article

57 Scopus citations

Abstract

One proposed mechanism for acute and chronic hepatic encephalopathy (HE) is a disturbance in cerebral energy metabolism. It also reviews the current status of this mechanism in both acute and chronic HE, as well as in other hyperammonemic disorders. It also reviews abnormalities in glycolysis, lactate metabolism, citric acid cycle, and oxidative phosphorylation as well as associated energy impairment. Additionally, the role of mitochondrial permeability transition (mPT), a recently established factor in the pathogenesis of HE and hyperammonemia, is emphasized. Energy failure appears to be an important pathogenetic component of both acute and chronic HE and a potential target for therapy.

Original languageEnglish (US)
Pages (from-to)697-706
Number of pages10
JournalNeurochemistry International
Volume60
Issue number7
DOIs
StatePublished - Jun 2012

Keywords

  • Ammonia
  • Astrocytes
  • Brain edema
  • Energy metabolism
  • Hepatic encephalopathy
  • Mitochondrial permeability transition
  • Oxidative stress

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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