Brain derived Neurotrophic factor and cognitive status: The delicate balance among people living with HIV, with and without Alcohol Abuse

María José Míguez-Burbano, Luis Espinoza, Nicole Ennis Whitehead, Vaughn E. Bryant, Mayra Vargas, Robert L. Cook, Clery Quiros, John E Lewis, Asthana Deshratan

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Introduction: The advent of combination antiretroviral therapy(cART) has lead to a significant reduction in morbidity and mortality among people living with HIV(PLWH). However, HIV-associated neurocognitive disorders (HAND) still remain a significant problem. One possible mechanism for the persistence of these disorders is through the effect of HIV on brain-derived neurotrophic factor (BDNF). BDNF is influenced by various factors including hazardous alcohol use (HAU), which is prevalent among PLWH. This study attempts to elucidate the relationships between HAU, BDNF and HAND. Methods: Cross-sectional analyses were conducted on a sample of 199 hazardous alcohol users and 198 non-HAU living with HIV. Members of each group were matched according to sociodemographic characteristics and CD4 count. Research procedures included validated questionnaires, neuropsychological assessments and a blood sample to obtain BDNF and immune measurements. Results: Hazardous alcohol users showed either significantly lower or significantly higher BDNF levels compared to the Non-hazardous (OR=1,4; 95% CI: 1-2.1, p = 0.003). Therefore, for additional analyses, subjects were categorized based on BDNF values in: Group 1 < 4000, Group 2: 4001-7,999 (reference group), and Group 3 for those >8,000 pg/mL. Groups 1 and 3 performed significantly worse than those in Group 2 in the domains of processing speed, auditory-verbal and visuospatial learning and memory. Multivariate analyses confirmed that HAU and BDNF are significant contributors of HAND. Conclusion: Our findings offer novel insights into the relationships between BDNF, and alcohol use among PLWH. Our results also lend support to expanding clinical movement to use BDNF as an intervention target for PLWH, in those with evidence of deficiencies, and highlight the importance of including HAUat the inception of clinical trials.

Original languageEnglish
Pages (from-to)254-264
Number of pages11
JournalCurrent HIV Research
Volume12
Issue number4
StatePublished - Jan 1 2014

Fingerprint

Brain-Derived Neurotrophic Factor
Alcoholism
HIV
Alcohols
Verbal Learning
CD4 Lymphocyte Count
Research Design
Multivariate Analysis
Cross-Sectional Studies
Clinical Trials
Morbidity
Mortality

Keywords

  • Alcohol drinking
  • BDNF
  • Hazardous alcohol use
  • HIV
  • Neurological disorders

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

Míguez-Burbano, M. J., Espinoza, L., Whitehead, N. E., Bryant, V. E., Vargas, M., Cook, R. L., ... Deshratan, A. (2014). Brain derived Neurotrophic factor and cognitive status: The delicate balance among people living with HIV, with and without Alcohol Abuse. Current HIV Research, 12(4), 254-264.

Brain derived Neurotrophic factor and cognitive status : The delicate balance among people living with HIV, with and without Alcohol Abuse. / Míguez-Burbano, María José; Espinoza, Luis; Whitehead, Nicole Ennis; Bryant, Vaughn E.; Vargas, Mayra; Cook, Robert L.; Quiros, Clery; Lewis, John E; Deshratan, Asthana.

In: Current HIV Research, Vol. 12, No. 4, 01.01.2014, p. 254-264.

Research output: Contribution to journalArticle

Míguez-Burbano, MJ, Espinoza, L, Whitehead, NE, Bryant, VE, Vargas, M, Cook, RL, Quiros, C, Lewis, JE & Deshratan, A 2014, 'Brain derived Neurotrophic factor and cognitive status: The delicate balance among people living with HIV, with and without Alcohol Abuse', Current HIV Research, vol. 12, no. 4, pp. 254-264.
Míguez-Burbano MJ, Espinoza L, Whitehead NE, Bryant VE, Vargas M, Cook RL et al. Brain derived Neurotrophic factor and cognitive status: The delicate balance among people living with HIV, with and without Alcohol Abuse. Current HIV Research. 2014 Jan 1;12(4):254-264.
Míguez-Burbano, María José ; Espinoza, Luis ; Whitehead, Nicole Ennis ; Bryant, Vaughn E. ; Vargas, Mayra ; Cook, Robert L. ; Quiros, Clery ; Lewis, John E ; Deshratan, Asthana. / Brain derived Neurotrophic factor and cognitive status : The delicate balance among people living with HIV, with and without Alcohol Abuse. In: Current HIV Research. 2014 ; Vol. 12, No. 4. pp. 254-264.
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