Brain atrophy in Huntington's disease - A CT-scan study

S. E. Starkstein, S. E. Folstein, J. Brandt, G. D. Pearlson, A. McDonnell, M. Folstein

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

CT-scan measurements of cortical and subcortical atrophy were carried out in 34 patients with Huntington's disease (HD). While a significant correlation was observed between parameters of subcortical atrophy (bicaudate ratio, bifrontal ratio and third ventricular ratio) and duration of the disease, there was no significant correlation between these parameters and age. On the other hand, measurements of cortical atrophy (frontal fissure ratio and cortical sulci ratio) correlated significantly with age but not with duration of the disease. When a group of 24 HD patients were compared on CT-scan measurements with a group of 24 age-matched normal controls, significant differences were obtained for all the variables examined, but the bicaudate ratio showed the highest sensitivity and specificity. Even mildly affected patients, with duration of motor symptoms less than 3 years had higher bicaudate ratios than age-matched controls.

Original languageEnglish
Pages (from-to)156-159
Number of pages4
JournalNeuroradiology
Volume31
Issue number2
DOIs
StatePublished - Mar 1 1989

Fingerprint

Huntington Disease
Atrophy
Brain
Age Groups
Sensitivity and Specificity

Keywords

  • Caudate
  • Corticol atrophy
  • Huntington's disease

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

Starkstein, S. E., Folstein, S. E., Brandt, J., Pearlson, G. D., McDonnell, A., & Folstein, M. (1989). Brain atrophy in Huntington's disease - A CT-scan study. Neuroradiology, 31(2), 156-159. https://doi.org/10.1007/BF00698845

Brain atrophy in Huntington's disease - A CT-scan study. / Starkstein, S. E.; Folstein, S. E.; Brandt, J.; Pearlson, G. D.; McDonnell, A.; Folstein, M.

In: Neuroradiology, Vol. 31, No. 2, 01.03.1989, p. 156-159.

Research output: Contribution to journalArticle

Starkstein, SE, Folstein, SE, Brandt, J, Pearlson, GD, McDonnell, A & Folstein, M 1989, 'Brain atrophy in Huntington's disease - A CT-scan study', Neuroradiology, vol. 31, no. 2, pp. 156-159. https://doi.org/10.1007/BF00698845
Starkstein SE, Folstein SE, Brandt J, Pearlson GD, McDonnell A, Folstein M. Brain atrophy in Huntington's disease - A CT-scan study. Neuroradiology. 1989 Mar 1;31(2):156-159. https://doi.org/10.1007/BF00698845
Starkstein, S. E. ; Folstein, S. E. ; Brandt, J. ; Pearlson, G. D. ; McDonnell, A. ; Folstein, M. / Brain atrophy in Huntington's disease - A CT-scan study. In: Neuroradiology. 1989 ; Vol. 31, No. 2. pp. 156-159.
@article{c362bfca8e414774a3a553ccfa162891,
title = "Brain atrophy in Huntington's disease - A CT-scan study",
abstract = "CT-scan measurements of cortical and subcortical atrophy were carried out in 34 patients with Huntington's disease (HD). While a significant correlation was observed between parameters of subcortical atrophy (bicaudate ratio, bifrontal ratio and third ventricular ratio) and duration of the disease, there was no significant correlation between these parameters and age. On the other hand, measurements of cortical atrophy (frontal fissure ratio and cortical sulci ratio) correlated significantly with age but not with duration of the disease. When a group of 24 HD patients were compared on CT-scan measurements with a group of 24 age-matched normal controls, significant differences were obtained for all the variables examined, but the bicaudate ratio showed the highest sensitivity and specificity. Even mildly affected patients, with duration of motor symptoms less than 3 years had higher bicaudate ratios than age-matched controls.",
keywords = "Caudate, Corticol atrophy, Huntington's disease",
author = "Starkstein, {S. E.} and Folstein, {S. E.} and J. Brandt and Pearlson, {G. D.} and A. McDonnell and M. Folstein",
year = "1989",
month = "3",
day = "1",
doi = "10.1007/BF00698845",
language = "English",
volume = "31",
pages = "156--159",
journal = "Neuroradiology",
issn = "0028-3940",
publisher = "Springer Verlag",
number = "2",

}

TY - JOUR

T1 - Brain atrophy in Huntington's disease - A CT-scan study

AU - Starkstein, S. E.

AU - Folstein, S. E.

AU - Brandt, J.

AU - Pearlson, G. D.

AU - McDonnell, A.

AU - Folstein, M.

PY - 1989/3/1

Y1 - 1989/3/1

N2 - CT-scan measurements of cortical and subcortical atrophy were carried out in 34 patients with Huntington's disease (HD). While a significant correlation was observed between parameters of subcortical atrophy (bicaudate ratio, bifrontal ratio and third ventricular ratio) and duration of the disease, there was no significant correlation between these parameters and age. On the other hand, measurements of cortical atrophy (frontal fissure ratio and cortical sulci ratio) correlated significantly with age but not with duration of the disease. When a group of 24 HD patients were compared on CT-scan measurements with a group of 24 age-matched normal controls, significant differences were obtained for all the variables examined, but the bicaudate ratio showed the highest sensitivity and specificity. Even mildly affected patients, with duration of motor symptoms less than 3 years had higher bicaudate ratios than age-matched controls.

AB - CT-scan measurements of cortical and subcortical atrophy were carried out in 34 patients with Huntington's disease (HD). While a significant correlation was observed between parameters of subcortical atrophy (bicaudate ratio, bifrontal ratio and third ventricular ratio) and duration of the disease, there was no significant correlation between these parameters and age. On the other hand, measurements of cortical atrophy (frontal fissure ratio and cortical sulci ratio) correlated significantly with age but not with duration of the disease. When a group of 24 HD patients were compared on CT-scan measurements with a group of 24 age-matched normal controls, significant differences were obtained for all the variables examined, but the bicaudate ratio showed the highest sensitivity and specificity. Even mildly affected patients, with duration of motor symptoms less than 3 years had higher bicaudate ratios than age-matched controls.

KW - Caudate

KW - Corticol atrophy

KW - Huntington's disease

UR - http://www.scopus.com/inward/record.url?scp=0024361618&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024361618&partnerID=8YFLogxK

U2 - 10.1007/BF00698845

DO - 10.1007/BF00698845

M3 - Article

VL - 31

SP - 156

EP - 159

JO - Neuroradiology

JF - Neuroradiology

SN - 0028-3940

IS - 2

ER -