Bradykinin, insulin, and glycemia responses to exercise performed above and below lactate threshold in individuals with type 2 diabetes

R. Y. Asano, R. A.V. Browne, M. M. Sales, G. Arsa, J. F.V.N. Moraes, H. J. Coelho-Júnior, M. R. Moraes, I. Oliveira-Silva, S. E. Atlas, John E Lewis, H. G. Simões

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The aim of this study was to analyze the acute responses of bradykinin, insulin, and glycemia to exercise performed above and below lactate threshold (LT) in individuals with type 2 diabetes mellitus (T2D). Eleven participants with a diagnosis of T2D randomly underwent three experimental sessions 72 h apart: 1) 20 min of exercise performed at 120% of LT (120%LT), 2) 20 min of exercise performed at 80% of LT (80%LT), and 3) 20 min of control session. Blood glucose was analyzed before, during, and at 45 min post-exercise. Bradykinin and insulin were analyzed before and at 45 min post-exercise. Both exercise sessions elicited a parallel decrease in glucose level during exercise (P≤0.002), with a greater decrease being observed for 120%LT (P=0.005). Glucose decreased 22.7 mg/dL (95%CI=10.3 to 35, P=0.001) at the 45 min post-exercise recovery period for 80%LT and decreased 31.2 mg/dL (95%CI=18.1 to 44.4, P<0.001) for 120%LT (P=0.004). Insulin decreased at post-exercise for 80%LT (P=0.001) and control (P≤0.035). Bradykinin increased at 45 min post-exercise only for 80%LT (P=0.013), but was unrelated to the decrease in glucose (r=–0.16, P=0.642). In conclusion, exercise performed above and below LT reduced glycemia independently of insulin, but exercise above LT was more effective in individuals with T2D. However, these changes were unrelated to the increase in circulating bradykinin.

Original languageEnglish (US)
Article numbere6400
JournalBrazilian Journal of Medical and Biological Research
Volume50
Issue number11
DOIs
StatePublished - 2017

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Bradykinin
Medical problems
Type 2 Diabetes Mellitus
Lactic Acid
Insulin
Glucose
Blood Glucose
Recovery

Keywords

  • Aerobic exercise
  • Insulin resistance
  • Metabolic disease
  • Peptide

ASJC Scopus subject areas

  • Biophysics
  • Neuroscience(all)
  • Biochemistry
  • Physiology
  • Immunology
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Cell Biology

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Bradykinin, insulin, and glycemia responses to exercise performed above and below lactate threshold in individuals with type 2 diabetes. / Asano, R. Y.; Browne, R. A.V.; Sales, M. M.; Arsa, G.; Moraes, J. F.V.N.; Coelho-Júnior, H. J.; Moraes, M. R.; Oliveira-Silva, I.; Atlas, S. E.; Lewis, John E; Simões, H. G.

In: Brazilian Journal of Medical and Biological Research, Vol. 50, No. 11, e6400, 2017.

Research output: Contribution to journalArticle

Asano, RY, Browne, RAV, Sales, MM, Arsa, G, Moraes, JFVN, Coelho-Júnior, HJ, Moraes, MR, Oliveira-Silva, I, Atlas, SE, Lewis, JE & Simões, HG 2017, 'Bradykinin, insulin, and glycemia responses to exercise performed above and below lactate threshold in individuals with type 2 diabetes', Brazilian Journal of Medical and Biological Research, vol. 50, no. 11, e6400. https://doi.org/10.1590/1414-431x20176400
Asano, R. Y. ; Browne, R. A.V. ; Sales, M. M. ; Arsa, G. ; Moraes, J. F.V.N. ; Coelho-Júnior, H. J. ; Moraes, M. R. ; Oliveira-Silva, I. ; Atlas, S. E. ; Lewis, John E ; Simões, H. G. / Bradykinin, insulin, and glycemia responses to exercise performed above and below lactate threshold in individuals with type 2 diabetes. In: Brazilian Journal of Medical and Biological Research. 2017 ; Vol. 50, No. 11.
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abstract = "The aim of this study was to analyze the acute responses of bradykinin, insulin, and glycemia to exercise performed above and below lactate threshold (LT) in individuals with type 2 diabetes mellitus (T2D). Eleven participants with a diagnosis of T2D randomly underwent three experimental sessions 72 h apart: 1) 20 min of exercise performed at 120{\%} of LT (120{\%}LT), 2) 20 min of exercise performed at 80{\%} of LT (80{\%}LT), and 3) 20 min of control session. Blood glucose was analyzed before, during, and at 45 min post-exercise. Bradykinin and insulin were analyzed before and at 45 min post-exercise. Both exercise sessions elicited a parallel decrease in glucose level during exercise (P≤0.002), with a greater decrease being observed for 120{\%}LT (P=0.005). Glucose decreased 22.7 mg/dL (95{\%}CI=10.3 to 35, P=0.001) at the 45 min post-exercise recovery period for 80{\%}LT and decreased 31.2 mg/dL (95{\%}CI=18.1 to 44.4, P<0.001) for 120{\%}LT (P=0.004). Insulin decreased at post-exercise for 80{\%}LT (P=0.001) and control (P≤0.035). Bradykinin increased at 45 min post-exercise only for 80{\%}LT (P=0.013), but was unrelated to the decrease in glucose (r=–0.16, P=0.642). In conclusion, exercise performed above and below LT reduced glycemia independently of insulin, but exercise above LT was more effective in individuals with T2D. However, these changes were unrelated to the increase in circulating bradykinin.",
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AU - Arsa, G.

AU - Moraes, J. F.V.N.

AU - Coelho-Júnior, H. J.

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AU - Oliveira-Silva, I.

AU - Atlas, S. E.

AU - Lewis, John E

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AB - The aim of this study was to analyze the acute responses of bradykinin, insulin, and glycemia to exercise performed above and below lactate threshold (LT) in individuals with type 2 diabetes mellitus (T2D). Eleven participants with a diagnosis of T2D randomly underwent three experimental sessions 72 h apart: 1) 20 min of exercise performed at 120% of LT (120%LT), 2) 20 min of exercise performed at 80% of LT (80%LT), and 3) 20 min of control session. Blood glucose was analyzed before, during, and at 45 min post-exercise. Bradykinin and insulin were analyzed before and at 45 min post-exercise. Both exercise sessions elicited a parallel decrease in glucose level during exercise (P≤0.002), with a greater decrease being observed for 120%LT (P=0.005). Glucose decreased 22.7 mg/dL (95%CI=10.3 to 35, P=0.001) at the 45 min post-exercise recovery period for 80%LT and decreased 31.2 mg/dL (95%CI=18.1 to 44.4, P<0.001) for 120%LT (P=0.004). Insulin decreased at post-exercise for 80%LT (P=0.001) and control (P≤0.035). Bradykinin increased at 45 min post-exercise only for 80%LT (P=0.013), but was unrelated to the decrease in glucose (r=–0.16, P=0.642). In conclusion, exercise performed above and below LT reduced glycemia independently of insulin, but exercise above LT was more effective in individuals with T2D. However, these changes were unrelated to the increase in circulating bradykinin.

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