Bradykinin B1 receptor-mediated changes in renal hemodynamics during endotoxin-induced inflammation

Joost P. Schanstra, Maria E. Marin-Castaño, Françoise Praddaude, Ivan Tack, Jean Louis Ader, Jean Pierre Girolami, Jean Loup Bascands, Benoit Jeunier

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Kinins have been shown to influence renal hemodynamics and function. Under physiologic conditions, most kinin effects involve bradykinin B2 receptors, but bradykinin B1 receptors are often induced during inflammation. The purpose of this study was to examine in vivo the effects of bradykinin B1 receptor activation on renal hemodynamics under normal and inflammatory conditions. In anesthetized rats, activation of bradykinin B1 receptors by arterial infusion of bradykinin B1 receptor agonist des-Arg9- bradykinin reduced renal plasma flow and GFR. Prior administration (18 h) of lipopolysaccharide to induce inflammation resulted in a larger bradykinin B1 receptor-induced reduction in renal plasma flow. Values of other parameters remained unchanged, thus resulting in an increased filtration fraction. The presence and the functionality of the bradykinin B1 receptor at the level of glomerular afferent and efferent arterioles were studied by mRNA expression analysis and intracellular calcium ([Ca2+](i)) mobilization studies. Stimulation with des-Arg9-bradykinin of microdissected afferent arterioles from control and lipopolysaccharide-treated rats induced [Ca2+](i) mobilization without any significant difference in amplitude between control and lipopolysaccharide-treated rats. However, des-Arg9-bradykinin only induced [Ca2+](i) mobilization in efferent arterioles from lipopolysaccharide-treated rats. It is suggested that activation of bradykinin B1 receptors located along the efferent arteriole may participate in the modification of renal hemodynamics in inflammatory states.

Original languageEnglish (US)
Pages (from-to)1208-1215
Number of pages8
JournalJournal of the American Society of Nephrology
Issue number7
StatePublished - Jul 1 2000

ASJC Scopus subject areas

  • Nephrology


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