Brachytherapy in the treatment of recurrent solitary brain metastases

Deborah O Heros, D. L. Kasdon, M. Chun, R. G. Selker

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Conventional therapy for solitary brain metastases includes radiotherapy and surgical resection in selected cases. Often, however, the metastasis recurs and limits the quality of life and survival of the patient. Once the metastasis recurs, therapeutic options are limited. Brachytherapy delivers a high total dose of radiation to a localized area, allowing reirradiation at the time of recurrence. Three patients with recurrent brain metastases treated with iridium-192 implants are presented; two of these patients had breast carcinoma and one had malignant melanoma. The implants allowed long term survival in the two patients with recurrent metastatic breast carcinoma. Unfortunately, the patient with melanoma did not respond to the brachytherapy and died within 7 months of implantation. The approaches to treatment to metastatic brain tumors and the rationale for using brachytherapy are discussed.

Original languageEnglish
Pages (from-to)733-737
Number of pages5
JournalNeurosurgery
Volume23
Issue number6
StatePublished - Dec 1 1988
Externally publishedYes

Fingerprint

Brachytherapy
Neoplasm Metastasis
Brain
Melanoma
Breast Neoplasms
Therapeutics
Iridium
Survival
Brain Neoplasms
Radiotherapy
Quality of Life
Radiation
Recurrence

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Heros, D. O., Kasdon, D. L., Chun, M., & Selker, R. G. (1988). Brachytherapy in the treatment of recurrent solitary brain metastases. Neurosurgery, 23(6), 733-737.

Brachytherapy in the treatment of recurrent solitary brain metastases. / Heros, Deborah O; Kasdon, D. L.; Chun, M.; Selker, R. G.

In: Neurosurgery, Vol. 23, No. 6, 01.12.1988, p. 733-737.

Research output: Contribution to journalArticle

Heros, DO, Kasdon, DL, Chun, M & Selker, RG 1988, 'Brachytherapy in the treatment of recurrent solitary brain metastases', Neurosurgery, vol. 23, no. 6, pp. 733-737.
Heros DO, Kasdon DL, Chun M, Selker RG. Brachytherapy in the treatment of recurrent solitary brain metastases. Neurosurgery. 1988 Dec 1;23(6):733-737.
Heros, Deborah O ; Kasdon, D. L. ; Chun, M. ; Selker, R. G. / Brachytherapy in the treatment of recurrent solitary brain metastases. In: Neurosurgery. 1988 ; Vol. 23, No. 6. pp. 733-737.
@article{777756b123f54a79a6f3b15be65cf543,
title = "Brachytherapy in the treatment of recurrent solitary brain metastases",
abstract = "Conventional therapy for solitary brain metastases includes radiotherapy and surgical resection in selected cases. Often, however, the metastasis recurs and limits the quality of life and survival of the patient. Once the metastasis recurs, therapeutic options are limited. Brachytherapy delivers a high total dose of radiation to a localized area, allowing reirradiation at the time of recurrence. Three patients with recurrent brain metastases treated with iridium-192 implants are presented; two of these patients had breast carcinoma and one had malignant melanoma. The implants allowed long term survival in the two patients with recurrent metastatic breast carcinoma. Unfortunately, the patient with melanoma did not respond to the brachytherapy and died within 7 months of implantation. The approaches to treatment to metastatic brain tumors and the rationale for using brachytherapy are discussed.",
author = "Heros, {Deborah O} and Kasdon, {D. L.} and M. Chun and Selker, {R. G.}",
year = "1988",
month = "12",
day = "1",
language = "English",
volume = "23",
pages = "733--737",
journal = "Neurosurgery",
issn = "0148-396X",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Brachytherapy in the treatment of recurrent solitary brain metastases

AU - Heros, Deborah O

AU - Kasdon, D. L.

AU - Chun, M.

AU - Selker, R. G.

PY - 1988/12/1

Y1 - 1988/12/1

N2 - Conventional therapy for solitary brain metastases includes radiotherapy and surgical resection in selected cases. Often, however, the metastasis recurs and limits the quality of life and survival of the patient. Once the metastasis recurs, therapeutic options are limited. Brachytherapy delivers a high total dose of radiation to a localized area, allowing reirradiation at the time of recurrence. Three patients with recurrent brain metastases treated with iridium-192 implants are presented; two of these patients had breast carcinoma and one had malignant melanoma. The implants allowed long term survival in the two patients with recurrent metastatic breast carcinoma. Unfortunately, the patient with melanoma did not respond to the brachytherapy and died within 7 months of implantation. The approaches to treatment to metastatic brain tumors and the rationale for using brachytherapy are discussed.

AB - Conventional therapy for solitary brain metastases includes radiotherapy and surgical resection in selected cases. Often, however, the metastasis recurs and limits the quality of life and survival of the patient. Once the metastasis recurs, therapeutic options are limited. Brachytherapy delivers a high total dose of radiation to a localized area, allowing reirradiation at the time of recurrence. Three patients with recurrent brain metastases treated with iridium-192 implants are presented; two of these patients had breast carcinoma and one had malignant melanoma. The implants allowed long term survival in the two patients with recurrent metastatic breast carcinoma. Unfortunately, the patient with melanoma did not respond to the brachytherapy and died within 7 months of implantation. The approaches to treatment to metastatic brain tumors and the rationale for using brachytherapy are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0024209665&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024209665&partnerID=8YFLogxK

M3 - Article

C2 - 3216971

AN - SCOPUS:0024209665

VL - 23

SP - 733

EP - 737

JO - Neurosurgery

JF - Neurosurgery

SN - 0148-396X

IS - 6

ER -