Bovine spongiform encephalopathy - Some surprises for biochemists

Peter N. Campbell, W. J. Whelan

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Bovine Spongiform Encephalopathy (BSE) is typical of the dementias that affect both animals and man; Scrapie in sheep, Creutzfeldt-Jakob disease in man. Global efforts have been made to determine the nature of the active agents in these diseases. At present the 'protein only hypothesis' of Prusiner holds. It was a surprise that a protein could per se be the active agent but other surprises for our traditional teaching of biochemistry arose. These are explained in a brief summary of our present understanding of the biochemistry of the active agents that cause the diseases.

Original languageEnglish (US)
Pages (from-to)273-276
Number of pages4
JournalIUBMB life
Issue number4-5
StatePublished - Apr 2005


  • Bovine Spongiform Encephalopathy
  • Prions
  • Scrapie

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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