Botulinum toxin improves sialorrhea and quality of living in bulbar amyotrophic lateral sclerosis

Ashok Verma, Julie Steele

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Sialorrhea is frequently a socially disabling symptom in patients with bulbar amyotrophic lateral sclerosis (ALS). In this open-label prospective study, we report the effect of botulinum toxin A (Botox) injection into the parotid glands in 10 patients with bulbar ALS and socially disabling sialorrhea. We applied three different outcome measures to determine the effect of Botox therapy on sialorrhea. Botox significantly improved the degree of sialorrhea and a drooling impact score and, by inference, the quality of living, in over half of the patients with bulbar ALS and severe sialorrhea. The beneficial effect of Botox lasted for at least 2 months in those who responded. No major adverse effects were noted. Local injection of a small dose of Botox into the parotid glands can control sialorrhea and potentially improve living quality in some patients with bulbar ALS.

Original languageEnglish
Pages (from-to)235-237
Number of pages3
JournalMuscle and Nerve
Volume34
Issue number2
DOIs
StatePublished - Aug 1 2006

Fingerprint

Sialorrhea
Botulinum Toxins
Amyotrophic Lateral Sclerosis
Type A Botulinum Toxins
Parotid Gland
Injections
Outcome Assessment (Health Care)
Prospective Studies

Keywords

  • ALS
  • Botulinum toxin
  • Drooling
  • Parotid gland
  • Quality of life
  • Sialorrhea

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Botulinum toxin improves sialorrhea and quality of living in bulbar amyotrophic lateral sclerosis. / Verma, Ashok; Steele, Julie.

In: Muscle and Nerve, Vol. 34, No. 2, 01.08.2006, p. 235-237.

Research output: Contribution to journalArticle

@article{77fb241f70ad4fb0a7c6e20b4540e7e3,
title = "Botulinum toxin improves sialorrhea and quality of living in bulbar amyotrophic lateral sclerosis",
abstract = "Sialorrhea is frequently a socially disabling symptom in patients with bulbar amyotrophic lateral sclerosis (ALS). In this open-label prospective study, we report the effect of botulinum toxin A (Botox) injection into the parotid glands in 10 patients with bulbar ALS and socially disabling sialorrhea. We applied three different outcome measures to determine the effect of Botox therapy on sialorrhea. Botox significantly improved the degree of sialorrhea and a drooling impact score and, by inference, the quality of living, in over half of the patients with bulbar ALS and severe sialorrhea. The beneficial effect of Botox lasted for at least 2 months in those who responded. No major adverse effects were noted. Local injection of a small dose of Botox into the parotid glands can control sialorrhea and potentially improve living quality in some patients with bulbar ALS.",
keywords = "ALS, Botulinum toxin, Drooling, Parotid gland, Quality of life, Sialorrhea",
author = "Ashok Verma and Julie Steele",
year = "2006",
month = "8",
day = "1",
doi = "10.1002/mus.20545",
language = "English",
volume = "34",
pages = "235--237",
journal = "Muscle and Nerve",
issn = "0148-639X",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - Botulinum toxin improves sialorrhea and quality of living in bulbar amyotrophic lateral sclerosis

AU - Verma, Ashok

AU - Steele, Julie

PY - 2006/8/1

Y1 - 2006/8/1

N2 - Sialorrhea is frequently a socially disabling symptom in patients with bulbar amyotrophic lateral sclerosis (ALS). In this open-label prospective study, we report the effect of botulinum toxin A (Botox) injection into the parotid glands in 10 patients with bulbar ALS and socially disabling sialorrhea. We applied three different outcome measures to determine the effect of Botox therapy on sialorrhea. Botox significantly improved the degree of sialorrhea and a drooling impact score and, by inference, the quality of living, in over half of the patients with bulbar ALS and severe sialorrhea. The beneficial effect of Botox lasted for at least 2 months in those who responded. No major adverse effects were noted. Local injection of a small dose of Botox into the parotid glands can control sialorrhea and potentially improve living quality in some patients with bulbar ALS.

AB - Sialorrhea is frequently a socially disabling symptom in patients with bulbar amyotrophic lateral sclerosis (ALS). In this open-label prospective study, we report the effect of botulinum toxin A (Botox) injection into the parotid glands in 10 patients with bulbar ALS and socially disabling sialorrhea. We applied three different outcome measures to determine the effect of Botox therapy on sialorrhea. Botox significantly improved the degree of sialorrhea and a drooling impact score and, by inference, the quality of living, in over half of the patients with bulbar ALS and severe sialorrhea. The beneficial effect of Botox lasted for at least 2 months in those who responded. No major adverse effects were noted. Local injection of a small dose of Botox into the parotid glands can control sialorrhea and potentially improve living quality in some patients with bulbar ALS.

KW - ALS

KW - Botulinum toxin

KW - Drooling

KW - Parotid gland

KW - Quality of life

KW - Sialorrhea

UR - http://www.scopus.com/inward/record.url?scp=33746668108&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746668108&partnerID=8YFLogxK

U2 - 10.1002/mus.20545

DO - 10.1002/mus.20545

M3 - Article

C2 - 16583370

AN - SCOPUS:33746668108

VL - 34

SP - 235

EP - 237

JO - Muscle and Nerve

JF - Muscle and Nerve

SN - 0148-639X

IS - 2

ER -