Abstract
Sialorrhea is frequently a socially disabling symptom in patients with bulbar amyotrophic lateral sclerosis (ALS). In this open-label prospective study, we report the effect of botulinum toxin A (Botox) injection into the parotid glands in 10 patients with bulbar ALS and socially disabling sialorrhea. We applied three different outcome measures to determine the effect of Botox therapy on sialorrhea. Botox significantly improved the degree of sialorrhea and a drooling impact score and, by inference, the quality of living, in over half of the patients with bulbar ALS and severe sialorrhea. The beneficial effect of Botox lasted for at least 2 months in those who responded. No major adverse effects were noted. Local injection of a small dose of Botox into the parotid glands can control sialorrhea and potentially improve living quality in some patients with bulbar ALS.
| Original language | English |
|---|---|
| Pages (from-to) | 235-237 |
| Number of pages | 3 |
| Journal | Muscle and Nerve |
| Volume | 34 |
| Issue number | 2 |
| DOIs | |
| State | Published - Aug 1 2006 |
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Keywords
- ALS
- Botulinum toxin
- Drooling
- Parotid gland
- Quality of life
- Sialorrhea
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Botulinum toxin improves sialorrhea and quality of living in bulbar amyotrophic lateral sclerosis. / Verma, Ashok; Steele, Julie.
In: Muscle and Nerve, Vol. 34, No. 2, 01.08.2006, p. 235-237.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Botulinum toxin improves sialorrhea and quality of living in bulbar amyotrophic lateral sclerosis
AU - Verma, Ashok
AU - Steele, Julie
PY - 2006/8/1
Y1 - 2006/8/1
N2 - Sialorrhea is frequently a socially disabling symptom in patients with bulbar amyotrophic lateral sclerosis (ALS). In this open-label prospective study, we report the effect of botulinum toxin A (Botox) injection into the parotid glands in 10 patients with bulbar ALS and socially disabling sialorrhea. We applied three different outcome measures to determine the effect of Botox therapy on sialorrhea. Botox significantly improved the degree of sialorrhea and a drooling impact score and, by inference, the quality of living, in over half of the patients with bulbar ALS and severe sialorrhea. The beneficial effect of Botox lasted for at least 2 months in those who responded. No major adverse effects were noted. Local injection of a small dose of Botox into the parotid glands can control sialorrhea and potentially improve living quality in some patients with bulbar ALS.
AB - Sialorrhea is frequently a socially disabling symptom in patients with bulbar amyotrophic lateral sclerosis (ALS). In this open-label prospective study, we report the effect of botulinum toxin A (Botox) injection into the parotid glands in 10 patients with bulbar ALS and socially disabling sialorrhea. We applied three different outcome measures to determine the effect of Botox therapy on sialorrhea. Botox significantly improved the degree of sialorrhea and a drooling impact score and, by inference, the quality of living, in over half of the patients with bulbar ALS and severe sialorrhea. The beneficial effect of Botox lasted for at least 2 months in those who responded. No major adverse effects were noted. Local injection of a small dose of Botox into the parotid glands can control sialorrhea and potentially improve living quality in some patients with bulbar ALS.
KW - ALS
KW - Botulinum toxin
KW - Drooling
KW - Parotid gland
KW - Quality of life
KW - Sialorrhea
UR - http://www.scopus.com/inward/record.url?scp=33746668108&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33746668108&partnerID=8YFLogxK
U2 - 10.1002/mus.20545
DO - 10.1002/mus.20545
M3 - Article
C2 - 16583370
AN - SCOPUS:33746668108
VL - 34
SP - 235
EP - 237
JO - Muscle and Nerve
JF - Muscle and Nerve
SN - 0148-639X
IS - 2
ER -