TY - JOUR
T1 - Bottle size and weight gain in formula-fed infants
AU - Wood, Charles T.
AU - Skinner, Asheley C.
AU - Yin, H. Shonna
AU - Rothman, Russell L.
AU - Sanders, Lee M.
AU - Delamater, Alan M.
AU - Perrin, Eliana M.
N1 - Funding Information:
Supported by National Institutes of Health (NIH)/Eunice Kennedy Shriver National Institute of Child Health and Human Development grant R01HD059794 with Centers for Disease Control and Prevention supplements 04S1 and 04S2; NIH grant UL1TR001111; NIH/National Center for Advancing Translational Sciences grant UL1TR000445; NIH/National Center for Research Resources grants U54RR023499, UL1RR025747, and UL1TR000038; Robert Wood Johnson Foundation Physician Faculty Scholars program (Dr Yin); and Health Resources and Services Administration grant T32HP014001. Funded by the National Institutes of Health (NIH).
PY - 2016/7
Y1 - 2016/7
N2 - BACKGROUND: Formula-fed infants may be at greater risk for overfeeding and rapid weight gain. Different size bottles are used for feeding infants, although little is known about whether bottle size is related to weight gain in bottle-fed infants. METHODS: Data from the Greenlight Intervention Study, a cluster randomized trial to prevent childhood obesity at 4 pediatric resident clinics, were used to analyze the exposure to regular (<6 oz) or large (≥6 oz) bottle size at the 2-month visit on changes in weight, weightfor- age z score (WAZ), and weight-for-length z score (WLZ) at the 6-month visit. Using multivariable regression, we adjusted for potential confounders (birth weight, gender, age, weight measures at 2 months, parent race/ethnicity, education, household income and size, time between 2- and 6-month visits, and first child status). RESULTS: Forty-five percent (n = 386; 41% black, 35% Hispanic, 23% white, 2% other) of infants at the 2-month visit were exclusively formula-fed, and 44% used large (≥6 oz) bottles. Infants whose parents fed with large bottles had 0.21 kg (95% confidence interval [CI]: 0.05 to 0.37) more weight change, 0.24 U (95% CI: 0.07 to 0.41) more change in WAZ, and 0.31 U (95% CI: 0.08 to 0.54) more change in WLZ during this period than infants fed with regular bottles. CONCLUSIONS: Using a large bottle in early infancy independently contributed to greater weight gain and change in WLZ at the 6-month visit. Although growth in infancy is complex, bottle size may be a modifiable risk factor for rapid infant weight gain and later obesity among exclusively formula-fed infants.
AB - BACKGROUND: Formula-fed infants may be at greater risk for overfeeding and rapid weight gain. Different size bottles are used for feeding infants, although little is known about whether bottle size is related to weight gain in bottle-fed infants. METHODS: Data from the Greenlight Intervention Study, a cluster randomized trial to prevent childhood obesity at 4 pediatric resident clinics, were used to analyze the exposure to regular (<6 oz) or large (≥6 oz) bottle size at the 2-month visit on changes in weight, weightfor- age z score (WAZ), and weight-for-length z score (WLZ) at the 6-month visit. Using multivariable regression, we adjusted for potential confounders (birth weight, gender, age, weight measures at 2 months, parent race/ethnicity, education, household income and size, time between 2- and 6-month visits, and first child status). RESULTS: Forty-five percent (n = 386; 41% black, 35% Hispanic, 23% white, 2% other) of infants at the 2-month visit were exclusively formula-fed, and 44% used large (≥6 oz) bottles. Infants whose parents fed with large bottles had 0.21 kg (95% confidence interval [CI]: 0.05 to 0.37) more weight change, 0.24 U (95% CI: 0.07 to 0.41) more change in WAZ, and 0.31 U (95% CI: 0.08 to 0.54) more change in WLZ during this period than infants fed with regular bottles. CONCLUSIONS: Using a large bottle in early infancy independently contributed to greater weight gain and change in WLZ at the 6-month visit. Although growth in infancy is complex, bottle size may be a modifiable risk factor for rapid infant weight gain and later obesity among exclusively formula-fed infants.
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U2 - 10.1542/peds.2015-4538
DO - 10.1542/peds.2015-4538
M3 - Article
C2 - 27273748
AN - SCOPUS:84976907955
VL - 138
JO - Pediatrics
JF - Pediatrics
SN - 0031-4005
IS - 1
M1 - e20154538
ER -