TY - JOUR
T1 - Bone Tissue Engineering via Carbon-Based Nanomaterials
AU - Peng, Zhili
AU - Zhao, Tianshu
AU - Zhou, Yiqun
AU - Li, Shanghao
AU - Li, Jiaojiao
AU - Leblanc, Roger M.
N1 - Funding Information:
Z.P. and T.Z. gratefully acknowledge the financial support from the National Natural Science Foundation of China (grant number: 21807010), the Applied Basic Research Program of Yunnan Province (grant number: 2019FB066), and the “Double‐First Class” University Construction Project (C176220100040) of Yunnan University. J.L. thanks the financial support from Yunnan University, China. Y.Z. and R.M.L. gratefully acknowledge the support of the National Science Foundation under Grant 011298.
Publisher Copyright:
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Bone tissue engineering (BTE) has received significant attention due to its enormous potential in treating critical-sized bone defects and related diseases. Traditional materials such as metals, ceramics, and polymers have been widely applied as BTE scaffolds; however, their clinical applications have been rather limited due to various considerations. Recently, carbon-based nanomaterials attract significant interests for their applications as BTE scaffolds due to their superior properties, including excellent mechanical strength, large surface area, tunable surface functionalities, high biocompatibility as well as abundant and inexpensive nature. In this article, recent studies and advancements on the use of carbon-based nanomaterials with different dimensions such as graphene and its derivatives, carbon nanotubes, and carbon dots, for BTE are reviewed. Current challenges of carbon-based nanomaterials for BTE and future trends in BTE scaffolds development are also highlighted and discussed.
AB - Bone tissue engineering (BTE) has received significant attention due to its enormous potential in treating critical-sized bone defects and related diseases. Traditional materials such as metals, ceramics, and polymers have been widely applied as BTE scaffolds; however, their clinical applications have been rather limited due to various considerations. Recently, carbon-based nanomaterials attract significant interests for their applications as BTE scaffolds due to their superior properties, including excellent mechanical strength, large surface area, tunable surface functionalities, high biocompatibility as well as abundant and inexpensive nature. In this article, recent studies and advancements on the use of carbon-based nanomaterials with different dimensions such as graphene and its derivatives, carbon nanotubes, and carbon dots, for BTE are reviewed. Current challenges of carbon-based nanomaterials for BTE and future trends in BTE scaffolds development are also highlighted and discussed.
KW - bone tissue engineering
KW - carbon dots
KW - carbon nanomaterials
KW - graphene oxide
KW - osteogenic differentiation
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U2 - 10.1002/adhm.201901495
DO - 10.1002/adhm.201901495
M3 - Review article
C2 - 31976623
AN - SCOPUS:85078805028
VL - 9
JO - Advanced healthcare materials
JF - Advanced healthcare materials
SN - 2192-2640
IS - 5
M1 - 1901495
ER -