Bone resorption stimulated by elevated serum 1,25-(OH)2-vitamin D concentrations in healthy men

W. J. Maierhofer, R. W. Gray, Herman S Cheung, J. Lemann

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

We evaluated whether calcitriol administration to healthy men stimulates bone resorption. We compared serum 1,25-(OH)2-D concentrations, Ca and PO4 balances, and urinary hydroxyproline excretion rates in four healthy men adapted to a low Ca diet providing only 4.0 ± 0.2 SD mmoles Ca/day to those in four healthy men eating a comparable diet (4.2 ± 0.9 mmoles Ca/day) during the chronic oral administration of calcitriol, 0.75 μg every 6 hr. Serum 1,25-(OH)2-D levels averaged 94 ± 16 pM during the control studies and 209 ± 35 pM during calcitriol administration. Net intestinal Ca absorption averaged 0.5 ± 0.3 mmoles/day during control and 1.8 ± 0.5 mmoles/day during calcitriol (P < 0.005), but urinary Ca excretion averaged 8.7 ± 2.0 mmoles/day during calcitriol as compared to 2.9 ± 1.4 mmoles/day day during control (P < 0.005). Thus, mean Ca balance, which averaged -2.4 ± 1.2 mmoles/day during control, was more negative during calcitriol at -6.3 ± 2.4 mmoles/day (P < 0.05). Average daily PO4 balances averaged +7.7 ± 1.5 mmoles/day during control but only tended to be negative during calcitriol at -1.1 ± 5.4 mmoles/day, (NS). Urinary hydroxyproline excretion averaged 0.26 ± 0.03 mmoles/day during control and 0.49 ± 0.06 during calcitriol (P < 0.001). We conclude that elevated serum 1,25-(OH)2-D concentrations in healthy men eating low Ca diets stimulate bone resorption.

Original languageEnglish
Pages (from-to)555-560
Number of pages6
JournalKidney International
Volume24
Issue number4
StatePublished - Dec 1 1983
Externally publishedYes

Fingerprint

Ergocalciferols
Calcitriol
Bone Resorption
Serum
Hydroxyproline
Diet
Intestinal Absorption
Oral Administration

ASJC Scopus subject areas

  • Nephrology

Cite this

Bone resorption stimulated by elevated serum 1,25-(OH)2-vitamin D concentrations in healthy men. / Maierhofer, W. J.; Gray, R. W.; Cheung, Herman S; Lemann, J.

In: Kidney International, Vol. 24, No. 4, 01.12.1983, p. 555-560.

Research output: Contribution to journalArticle

Maierhofer, W. J. ; Gray, R. W. ; Cheung, Herman S ; Lemann, J. / Bone resorption stimulated by elevated serum 1,25-(OH)2-vitamin D concentrations in healthy men. In: Kidney International. 1983 ; Vol. 24, No. 4. pp. 555-560.
@article{db63acefc0204138a74929bd41f07a5c,
title = "Bone resorption stimulated by elevated serum 1,25-(OH)2-vitamin D concentrations in healthy men",
abstract = "We evaluated whether calcitriol administration to healthy men stimulates bone resorption. We compared serum 1,25-(OH)2-D concentrations, Ca and PO4 balances, and urinary hydroxyproline excretion rates in four healthy men adapted to a low Ca diet providing only 4.0 ± 0.2 SD mmoles Ca/day to those in four healthy men eating a comparable diet (4.2 ± 0.9 mmoles Ca/day) during the chronic oral administration of calcitriol, 0.75 μg every 6 hr. Serum 1,25-(OH)2-D levels averaged 94 ± 16 pM during the control studies and 209 ± 35 pM during calcitriol administration. Net intestinal Ca absorption averaged 0.5 ± 0.3 mmoles/day during control and 1.8 ± 0.5 mmoles/day during calcitriol (P < 0.005), but urinary Ca excretion averaged 8.7 ± 2.0 mmoles/day during calcitriol as compared to 2.9 ± 1.4 mmoles/day day during control (P < 0.005). Thus, mean Ca balance, which averaged -2.4 ± 1.2 mmoles/day during control, was more negative during calcitriol at -6.3 ± 2.4 mmoles/day (P < 0.05). Average daily PO4 balances averaged +7.7 ± 1.5 mmoles/day during control but only tended to be negative during calcitriol at -1.1 ± 5.4 mmoles/day, (NS). Urinary hydroxyproline excretion averaged 0.26 ± 0.03 mmoles/day during control and 0.49 ± 0.06 during calcitriol (P < 0.001). We conclude that elevated serum 1,25-(OH)2-D concentrations in healthy men eating low Ca diets stimulate bone resorption.",
author = "Maierhofer, {W. J.} and Gray, {R. W.} and Cheung, {Herman S} and J. Lemann",
year = "1983",
month = "12",
day = "1",
language = "English",
volume = "24",
pages = "555--560",
journal = "Kidney International",
issn = "0085-2538",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - Bone resorption stimulated by elevated serum 1,25-(OH)2-vitamin D concentrations in healthy men

AU - Maierhofer, W. J.

AU - Gray, R. W.

AU - Cheung, Herman S

AU - Lemann, J.

PY - 1983/12/1

Y1 - 1983/12/1

N2 - We evaluated whether calcitriol administration to healthy men stimulates bone resorption. We compared serum 1,25-(OH)2-D concentrations, Ca and PO4 balances, and urinary hydroxyproline excretion rates in four healthy men adapted to a low Ca diet providing only 4.0 ± 0.2 SD mmoles Ca/day to those in four healthy men eating a comparable diet (4.2 ± 0.9 mmoles Ca/day) during the chronic oral administration of calcitriol, 0.75 μg every 6 hr. Serum 1,25-(OH)2-D levels averaged 94 ± 16 pM during the control studies and 209 ± 35 pM during calcitriol administration. Net intestinal Ca absorption averaged 0.5 ± 0.3 mmoles/day during control and 1.8 ± 0.5 mmoles/day during calcitriol (P < 0.005), but urinary Ca excretion averaged 8.7 ± 2.0 mmoles/day during calcitriol as compared to 2.9 ± 1.4 mmoles/day day during control (P < 0.005). Thus, mean Ca balance, which averaged -2.4 ± 1.2 mmoles/day during control, was more negative during calcitriol at -6.3 ± 2.4 mmoles/day (P < 0.05). Average daily PO4 balances averaged +7.7 ± 1.5 mmoles/day during control but only tended to be negative during calcitriol at -1.1 ± 5.4 mmoles/day, (NS). Urinary hydroxyproline excretion averaged 0.26 ± 0.03 mmoles/day during control and 0.49 ± 0.06 during calcitriol (P < 0.001). We conclude that elevated serum 1,25-(OH)2-D concentrations in healthy men eating low Ca diets stimulate bone resorption.

AB - We evaluated whether calcitriol administration to healthy men stimulates bone resorption. We compared serum 1,25-(OH)2-D concentrations, Ca and PO4 balances, and urinary hydroxyproline excretion rates in four healthy men adapted to a low Ca diet providing only 4.0 ± 0.2 SD mmoles Ca/day to those in four healthy men eating a comparable diet (4.2 ± 0.9 mmoles Ca/day) during the chronic oral administration of calcitriol, 0.75 μg every 6 hr. Serum 1,25-(OH)2-D levels averaged 94 ± 16 pM during the control studies and 209 ± 35 pM during calcitriol administration. Net intestinal Ca absorption averaged 0.5 ± 0.3 mmoles/day during control and 1.8 ± 0.5 mmoles/day during calcitriol (P < 0.005), but urinary Ca excretion averaged 8.7 ± 2.0 mmoles/day during calcitriol as compared to 2.9 ± 1.4 mmoles/day day during control (P < 0.005). Thus, mean Ca balance, which averaged -2.4 ± 1.2 mmoles/day during control, was more negative during calcitriol at -6.3 ± 2.4 mmoles/day (P < 0.05). Average daily PO4 balances averaged +7.7 ± 1.5 mmoles/day during control but only tended to be negative during calcitriol at -1.1 ± 5.4 mmoles/day, (NS). Urinary hydroxyproline excretion averaged 0.26 ± 0.03 mmoles/day during control and 0.49 ± 0.06 during calcitriol (P < 0.001). We conclude that elevated serum 1,25-(OH)2-D concentrations in healthy men eating low Ca diets stimulate bone resorption.

UR - http://www.scopus.com/inward/record.url?scp=0021070580&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021070580&partnerID=8YFLogxK

M3 - Article

VL - 24

SP - 555

EP - 560

JO - Kidney International

JF - Kidney International

SN - 0085-2538

IS - 4

ER -