Bone repair with skeletal stem cells: rationale, progress to date and clinical application

Elena A. Jones, Peter V. Giannoudis, Dimitrios Kouroupis

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Bone marrow (BM) contains stem cells for both hematopoietic and nonhematopoietic lineages. Hematopoietic stem cells enable hematopoiesis to occur in a controlled manner in order to accurately compensate for the loss of short- as well as long-lived mature blood cells. The physiological role of nonhematopoietic BM stem cells, often referred to as multipotential stromal cells or skeletal stem cells (SSCs), is less understood. According to an authoritative current opinion, the main function of SSCs is to give rise to cartilage, bone, marrow fat and hematopoiesis-supportive stroma, in a specific sequence during embryonic and postnatal development. This review outlines recent advances in the understanding of origins and homeostatic functions of SSCs in vivo and highlights current and future SSC-based treatments for skeletal and joint disorders.

Original languageEnglish (US)
Pages (from-to)57-71
Number of pages15
JournalTherapeutic Advances in Musculoskeletal Disease
Volume8
Issue number3
DOIs
StatePublished - Jun 2016
Externally publishedYes

Keywords

  • bone repair
  • hematopoietic stem cells
  • multipotential stromal cells
  • osteoarthritis
  • skeletal stem cells
  • systemic bone diseases

ASJC Scopus subject areas

  • Rheumatology
  • Orthopedics and Sports Medicine

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