Bone mineralization and metabolism of3H-25-hydroxyvitamin D3 in thyroparathyroidectomized rats treated with parathyroid extract

J. I. Rader, G. A. Howard, E. Feist, R. T. Turner, D. J. Baylink

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Thyroparathyroidectomized rats fed a diet containing 1.2% calcium, 0.55% phosphorus maintain normal serum levels of these ions. Treatment of such rats with parathyroid extract (PTE; 20 U/100 g twice daily; 10 days) has no statistically significant effect on rates of bone formation, matrix apposition, or osteoid maturation. Significant decreases in osteoid width and mineralizing front width, as well as a 60% increase in the rate of initial mineralization were observed in the PTE-treated group. Conversion of3H-25-hydroxyvitamin D3 to3H-1,25-dihydroxyvitamin D3 was 4-fold higher in the PTE-treated group than in the untreated animals. Increased formation of 1,25-dihydroxyvitamin D3 in response to treatment with PTE may play a major role in correcting the mineralizing defect resulting from thyroparathyroidectomy.

Original languageEnglish (US)
Pages (from-to)21-26
Number of pages6
JournalCalcified Tissue International
Volume29
Issue number1
DOIs
StatePublished - Dec 1 1979
Externally publishedYes

Keywords

  • 1,25-Dihydroxyvitamin D
  • 25-Hydroxyvitamin D
  • Mineral metabolism
  • Parathyroid extract
  • Thyroparathyroidectomy

ASJC Scopus subject areas

  • Endocrinology
  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism

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