Bone marrow transplantation for sickle cell anemia

M. R. Abboud, S. M. Jackson, Julio Barredo, J. Beatty, J. Laver

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose: To investigate the role of bone marrow transplantation in patients with severe sickle cell anemia (SCA). Patients and Methods: We have designed a protocol for selecting patients with severe SCA who may benefit from bone marrow transplantation (BMT). On the basis of this protocol, a girl 3 9/12 years of age who had severe recurrent pain crises and splenic dysfunction received a BMT from her brother, who is homozygous for hemoglobin A. Results: Transplantation resulted in prompt engraftment, followed by durable hematologic and immunologic reconstitution with donor cells. One year after BMT, the patient continued to do well. She did not experience any graft versus host disease, her growth velocity increased, and recovery of splenic function was demonstrated. Since undergoing BMT, she has not experienced any painful crises. Conclusions: Bone marrow transplantation is an effective therapeutic modality that should be considered in patients with severe SCA.

Original languageEnglish
Pages (from-to)86-89
Number of pages4
JournalAmerican Journal of Pediatric Hematology/Oncology
Volume16
Issue number1
StatePublished - Jan 1 1994
Externally publishedYes

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Sickle Cell Anemia
Bone Marrow Transplantation
Hemoglobin A
Recovery of Function
Graft vs Host Disease
Siblings
Transplantation
Tissue Donors
Pain
Growth

Keywords

  • Bone marrow transplantation
  • Sickle cell anemia

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Pediatrics, Perinatology, and Child Health

Cite this

Abboud, M. R., Jackson, S. M., Barredo, J., Beatty, J., & Laver, J. (1994). Bone marrow transplantation for sickle cell anemia. American Journal of Pediatric Hematology/Oncology, 16(1), 86-89.

Bone marrow transplantation for sickle cell anemia. / Abboud, M. R.; Jackson, S. M.; Barredo, Julio; Beatty, J.; Laver, J.

In: American Journal of Pediatric Hematology/Oncology, Vol. 16, No. 1, 01.01.1994, p. 86-89.

Research output: Contribution to journalArticle

Abboud, MR, Jackson, SM, Barredo, J, Beatty, J & Laver, J 1994, 'Bone marrow transplantation for sickle cell anemia', American Journal of Pediatric Hematology/Oncology, vol. 16, no. 1, pp. 86-89.
Abboud, M. R. ; Jackson, S. M. ; Barredo, Julio ; Beatty, J. ; Laver, J. / Bone marrow transplantation for sickle cell anemia. In: American Journal of Pediatric Hematology/Oncology. 1994 ; Vol. 16, No. 1. pp. 86-89.
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