Bone marrow transplantation for severe aplastic Anemia: Effect of a preparative regimen of cyclophosphamide-low-dose total-lymphoid irradiation and posttransplant cyclosporine-methotrexate therapy

R. E. Champlin, W. G. Ho, S. D. Nimer, J. G. Gajewski, M. Selch, M. Burnison, G. Holley, P. Yam, L. Petz, D. J. Winston, S. A. Feig

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Twenty-nine patients with severe aplastic anemia were entered into a study of pre- and posttransplant immunosuppressive therapy for bone marrow transplantation. Four of twenty-five previously transfused recipients prepared with cyclophosphamide 200 mg/kg and total-lymphoid irradiation 3 Gy experienced graft failure, indicating that this regimen was inadequate to ensure sustained engraftment. Posttransplant treatment with cyclosporine and methotrexate resulted in an actuarial incidence for grade ≥ 2 graft-versus-host disease of 22 ± 16%. Actuarial survival was 78 ± 15%. These data indicate that more effective treatment is necessary to prevent graft failure, but since many patients can be successfully retransplanted, overall survival is comparable to other recent studies.

Original languageEnglish (US)
Pages (from-to)720-724
Number of pages5
JournalTransplantation
Volume49
Issue number4
DOIs
StatePublished - Apr 1990
Externally publishedYes

ASJC Scopus subject areas

  • Transplantation

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