Bone marrow transplantation for severe aplastic anemia: Effect of a preparative regimen of cyclophosphamide-low-dose total-lymphoid irradiation and posttransplant cyclosporine-methotrexate therapy

R. E. Champlin, W. G. Ho, Stephen D Nimer, J. G. Gajewski, M. Selch, M. Burnison, G. Holley, P. Yam, L. Petz, D. J. Winston, S. A. Feig

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Twenty-nine patients with severe aplastic anemia were entered into a study of pre- and posttransplant immunosuppressive therapy for bone marrow transplantation. Four of twenty-five previously transfused recipients prepared with cyclophosphamide 200 mg/kg and total-lymphoid irradiation 3 Gy experienced graft failure, indicating that this regimen was inadequate to ensure sustained engraftment. Posttransplant treatment with cyclosporine and methotrexate resulted in an actuarial incidence for grade ≥ 2 graft-versus-host disease of 22 ± 16%. Actuarial survival was 78 ± 15%. These data indicate that more effective treatment is necessary to prevent graft failure, but since many patients can be successfully retransplanted, overall survival is comparable to other recent studies.

Original languageEnglish
Pages (from-to)720-724
Number of pages5
JournalTransplantation
Volume49
Issue number4
StatePublished - Jan 1 1990
Externally publishedYes

Fingerprint

Lymphatic Irradiation
Aplastic Anemia
Bone Marrow Transplantation
Methotrexate
Cyclophosphamide
Cyclosporine
Transplants
Survival
Graft vs Host Disease
Immunosuppressive Agents
Therapeutics
Incidence

ASJC Scopus subject areas

  • Immunology
  • Transplantation

Cite this

Bone marrow transplantation for severe aplastic anemia : Effect of a preparative regimen of cyclophosphamide-low-dose total-lymphoid irradiation and posttransplant cyclosporine-methotrexate therapy. / Champlin, R. E.; Ho, W. G.; Nimer, Stephen D; Gajewski, J. G.; Selch, M.; Burnison, M.; Holley, G.; Yam, P.; Petz, L.; Winston, D. J.; Feig, S. A.

In: Transplantation, Vol. 49, No. 4, 01.01.1990, p. 720-724.

Research output: Contribution to journalArticle

Champlin, RE, Ho, WG, Nimer, SD, Gajewski, JG, Selch, M, Burnison, M, Holley, G, Yam, P, Petz, L, Winston, DJ & Feig, SA 1990, 'Bone marrow transplantation for severe aplastic anemia: Effect of a preparative regimen of cyclophosphamide-low-dose total-lymphoid irradiation and posttransplant cyclosporine-methotrexate therapy', Transplantation, vol. 49, no. 4, pp. 720-724.
Champlin, R. E. ; Ho, W. G. ; Nimer, Stephen D ; Gajewski, J. G. ; Selch, M. ; Burnison, M. ; Holley, G. ; Yam, P. ; Petz, L. ; Winston, D. J. ; Feig, S. A. / Bone marrow transplantation for severe aplastic anemia : Effect of a preparative regimen of cyclophosphamide-low-dose total-lymphoid irradiation and posttransplant cyclosporine-methotrexate therapy. In: Transplantation. 1990 ; Vol. 49, No. 4. pp. 720-724.
@article{5bf442fe2ff646c3ac52ff961e080264,
title = "Bone marrow transplantation for severe aplastic anemia: Effect of a preparative regimen of cyclophosphamide-low-dose total-lymphoid irradiation and posttransplant cyclosporine-methotrexate therapy",
abstract = "Twenty-nine patients with severe aplastic anemia were entered into a study of pre- and posttransplant immunosuppressive therapy for bone marrow transplantation. Four of twenty-five previously transfused recipients prepared with cyclophosphamide 200 mg/kg and total-lymphoid irradiation 3 Gy experienced graft failure, indicating that this regimen was inadequate to ensure sustained engraftment. Posttransplant treatment with cyclosporine and methotrexate resulted in an actuarial incidence for grade ≥ 2 graft-versus-host disease of 22 ± 16{\%}. Actuarial survival was 78 ± 15{\%}. These data indicate that more effective treatment is necessary to prevent graft failure, but since many patients can be successfully retransplanted, overall survival is comparable to other recent studies.",
author = "Champlin, {R. E.} and Ho, {W. G.} and Nimer, {Stephen D} and Gajewski, {J. G.} and M. Selch and M. Burnison and G. Holley and P. Yam and L. Petz and Winston, {D. J.} and Feig, {S. A.}",
year = "1990",
month = "1",
day = "1",
language = "English",
volume = "49",
pages = "720--724",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Bone marrow transplantation for severe aplastic anemia

T2 - Effect of a preparative regimen of cyclophosphamide-low-dose total-lymphoid irradiation and posttransplant cyclosporine-methotrexate therapy

AU - Champlin, R. E.

AU - Ho, W. G.

AU - Nimer, Stephen D

AU - Gajewski, J. G.

AU - Selch, M.

AU - Burnison, M.

AU - Holley, G.

AU - Yam, P.

AU - Petz, L.

AU - Winston, D. J.

AU - Feig, S. A.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - Twenty-nine patients with severe aplastic anemia were entered into a study of pre- and posttransplant immunosuppressive therapy for bone marrow transplantation. Four of twenty-five previously transfused recipients prepared with cyclophosphamide 200 mg/kg and total-lymphoid irradiation 3 Gy experienced graft failure, indicating that this regimen was inadequate to ensure sustained engraftment. Posttransplant treatment with cyclosporine and methotrexate resulted in an actuarial incidence for grade ≥ 2 graft-versus-host disease of 22 ± 16%. Actuarial survival was 78 ± 15%. These data indicate that more effective treatment is necessary to prevent graft failure, but since many patients can be successfully retransplanted, overall survival is comparable to other recent studies.

AB - Twenty-nine patients with severe aplastic anemia were entered into a study of pre- and posttransplant immunosuppressive therapy for bone marrow transplantation. Four of twenty-five previously transfused recipients prepared with cyclophosphamide 200 mg/kg and total-lymphoid irradiation 3 Gy experienced graft failure, indicating that this regimen was inadequate to ensure sustained engraftment. Posttransplant treatment with cyclosporine and methotrexate resulted in an actuarial incidence for grade ≥ 2 graft-versus-host disease of 22 ± 16%. Actuarial survival was 78 ± 15%. These data indicate that more effective treatment is necessary to prevent graft failure, but since many patients can be successfully retransplanted, overall survival is comparable to other recent studies.

UR - http://www.scopus.com/inward/record.url?scp=0025253554&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025253554&partnerID=8YFLogxK

M3 - Article

C2 - 2326866

AN - SCOPUS:0025253554

VL - 49

SP - 720

EP - 724

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 4

ER -