Bone graft and bone substitute biology

Harshpal Singh, Allan D Levi

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations


Autologous bone graft (autograft) is defined as bone graft material harvested from the host. It can either be taken locally from the surgical site or from a distant donor site. Bone graft substitutes are synthetic or allograft derived substrates created to enhance fusion. They can be subdivided into many different categories including allografts, ceramics, demineralized bone matrix, osteoinductive factors, autogenous platelet concentrate, mesenchymal stem cells, and gene therapy. The various options possess different biologic and physiologic attributes which, depending on the surgical need, make them the preferential choice as a fusion adjunct.

Original languageEnglish (US)
Title of host publicationSpine Surgery Basics
PublisherSpringer Berlin Heidelberg
Number of pages6
ISBN (Print)9783642341267, 9783642341250
StatePublished - Jan 1 2014


ASJC Scopus subject areas

  • Medicine(all)

Cite this

Singh, H., & Levi, A. D. (2014). Bone graft and bone substitute biology. In Spine Surgery Basics (pp. 147-152). Springer Berlin Heidelberg.