Bone disease in multiple myeloma and precursor disease: Novel diagnostic approaches and implications on clinical management

Sigurdur Y. Kristinsson, Alex R. Minter, Neha Korde, Esther Tan, Ola Landgren

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

The manifestations of bone involvement in patients with multiple myeloma (MM) can have devastating clinical effects and increase mortality. Recent studies demonstrate that patients with the precursor conditions smoldering MM (SMM) and monoclonal gammopathy of undetermined significance (MGUS) show evidence of bone disease and increased risk of fractures. The understanding of the pathogenesis of bone disease in MM has expanded in recent years. The traditional skeletal survey will probably be replaced by newer and more sensitive imaging techniques, which may have a prognostic impact and change our definition of MGUS and SMM. Bisphosphonates are recommended to prevent skeletal events in patients with MM, and have also been studied in SMM and MGUS. This article summarizes the current knowledge of bone disease in plasma cell disorders, and discusses the current standard and future role of novel imaging techniques, as well as the evidence and current guidelines for bisphosphonates in MM, SMM and MGUS.

Original languageEnglish (US)
Pages (from-to)593-603
Number of pages11
JournalExpert Review of Molecular Diagnostics
Volume11
Issue number6
DOIs
StatePublished - Jul 2011
Externally publishedYes

Keywords

  • bisphosphonates
  • bone disease
  • fractures
  • MGUS
  • multiple myeloma
  • radiology
  • smoldering multiple myeloma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Molecular Biology
  • Genetics

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