Bombesin-induced locomotor hyperactivity: evaluation of the involvement of the mesolimbic dopamine system

David W. Schulz, Peter W. Kalivas, Charles B. Nemeroff, Arthur J. Prange

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

The neuropeptide bombesin was administered centrally to conscious, unrestrained rats. Bombesin caused a dose-dependent increase in locomotor behavior, as well as licking and grooming. The effect on locomotion was most readily elicited when bombesin was infused into the nucleus accumbens, and was attenuated by pretreatment with haloperidol but not atropine or diphenhydramine. Centrally administered bombesin did not change regional levels of dopamine or its principal metabolites.

Original languageEnglish (US)
Pages (from-to)377-382
Number of pages6
JournalBrain Research
Volume304
Issue number2
DOIs
StatePublished - Jun 25 1984
Externally publishedYes

Keywords

  • bombesin
  • locomotor behavior
  • mesolimbic dopamine system

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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