Regulação da massa corpórea pelo estrogênio e pela atividade física

Translated title of the contribution: Body mass regulation by estrogen and physical activity

Daniele L. Ignacio, Tamar G.P. Frankenfeld, Rodrigo S. Fortunato, Mário Vaisman, João Pedro Saar Werneck-de-Castro, Denise P. Carvalho

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Female steroid hormones deficiency leads to a significant increase in body mass, but the possible central and peripheral mechanisms involved in increased food ingestion and fat accumulation in this situation are still unknown. In animal models, the specific lack of estrogen or its action produce progressive body mass gain, clearly demonstrating the possible role of this hormone in overweight after menopause. Obesity and overweight correspond to a relevant human health problem that can lead to premature death. Therefore unraveling the mechanisms underlying body mass gain is of great relevance, as well as the development of strategies to prevent its establishment. Energy balance regulation is associated with the control of body mass, and physical exercise is an important modulator of this homeostatic parameter. However, the influence of physical exercise in mass gain development during estrogen deficiency is controversial and depends on the exercise protocol used. In this study, we intend to review the data on the effects of estrogen deficiency on body mass gain in humans and animal models.

Translated title of the contributionBody mass regulation by estrogen and physical activity
Original languagePortuguese
Pages (from-to)310-317
Number of pages8
JournalArquivos brasileiros de endocrinologia e metabologia
Issue number3
StatePublished - 2009
Externally publishedYes


  • Estrogens
  • Exercise
  • Menopause
  • Ovariectomy
  • Overweight

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


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