BMP growth factors and Phox2 transcription factors can induce synaptotagmin I and neurexin I during sympathetic neuron development

Holger Patzke, Eva Reissmann, Matthias Stanke, John Bixby, Uwe Ernsberger

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Synaptotagmin I and neurexin I mRNAs, coding for proteins involved in neurotransmitter secretion, become detectable in primary sympathetic ganglia shortly after initial induction of the noradrenergic transmitter phenotype. To test whether the induction of these more general neuronal genes is mediated by signals known to initiate noradrenergic differentiation in a neuronal subpopulation, we examined their expression in noradrenergic neurons induced by ectopic overexpression of growth and transcription factors. Overexpression of BMP4 or Phox2a in vivo results in synaptotagmin I and neurexin I expression in ectopically located noradrenergic cells. In vitro, BMP4 initiates synaptotagmin I and neurexin I expression in addition to tyrosine hydroxylase induction. Thus, the induction of synaptotagmin I and neurexin I, which are expressed in a large number of different neuron populations, can be accomplished by growth and transcription factors available only to a subset of neurons. These findings suggest that the initial expression of proteins involved in neurotransmitter secretion is regulated by different signals in different neuron populations.

Original languageEnglish
Pages (from-to)149-159
Number of pages11
JournalMechanisms of Development
Volume108
Issue number1-2
DOIs
StatePublished - Oct 11 2001

Fingerprint

Synaptotagmin I
Intercellular Signaling Peptides and Proteins
Transcription Factors
Neurons
Neurotransmitter Agents
Adrenergic Neurons
Sympathetic Ganglia
Tyrosine 3-Monooxygenase
Population
Proteins
Phenotype
Messenger RNA
Genes

Keywords

  • Bone morphogenetic protein
  • Development
  • Induction
  • Neurexin
  • Neuronal
  • Phox2
  • Sympathetic
  • Synaptotagmin

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

BMP growth factors and Phox2 transcription factors can induce synaptotagmin I and neurexin I during sympathetic neuron development. / Patzke, Holger; Reissmann, Eva; Stanke, Matthias; Bixby, John; Ernsberger, Uwe.

In: Mechanisms of Development, Vol. 108, No. 1-2, 11.10.2001, p. 149-159.

Research output: Contribution to journalArticle

Patzke, Holger ; Reissmann, Eva ; Stanke, Matthias ; Bixby, John ; Ernsberger, Uwe. / BMP growth factors and Phox2 transcription factors can induce synaptotagmin I and neurexin I during sympathetic neuron development. In: Mechanisms of Development. 2001 ; Vol. 108, No. 1-2. pp. 149-159.
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